Acide Shikimic Ac

Acide ya Shikimic (3,4,5-trihydroxy-1-cyclohexene-1-karubasi ya acide) ni ibinyabuzima bisanzwe biboneka kama ningirakamaro hagati ya biosynthesis ya lignin, acide amine aromatic (phenylalanine, tyrosine na tryptophan), nibindi byinshi ibimera na mikorobe ya alkaloide.

Acide ya Shikimic isanzwe ikoreshwa nkibikoresho byo gutangiza inganda zo mu bwoko bwa oseltamivir ya virusi ya virusi (imiti igabanya ubukana bwa H5N1 ikoreshwa mu kuvura no gukumira ubwoko bwose buzwi bwa virusi ya grippe). Synthesis ya (-) - zeylenone ishingiye kuri Acide ya Shikimic yavuzwe ko ikoreshwa cyane nkumukozi wa chimiotherapie ya kanseri. Amakuru arahari kuri synthesis ya monopalmitoyloxy Shikimic Acide, ifite ibikorwa bya anticoagulant kandi ikaba ishobora kugabanya umuvuduko wamaraso mugihe itanzwe muburyo budasanzwe. Itsinda ry’ubushakashatsi bw’Abashinwa ryashushanyije inkomoko ya Shikimic Acide, triacetyl Shikimic Acide, igaragaza ibikorwa bya anticagulant na antithrombotic.

Byongeye kandi, inkomoko ya Acide ya Shikimic yerekanye ko ishishikajwe cyane n’ubuhinzi kuko inyinshi muri zo zikoreshwa nk'imiti yica ibyatsi n’imiti igabanya ubukana kuko zishobora guhagarika inzira ya Acide ya Shikimic mu bimera na bagiteri bitagize ingaruka mbi ku nyamaswa.

Rero, Acide Shikimic irashobora gukoreshwa nkigisubizo cya synthesis organique haba mubumenyi bwibanze nubuvuzi bukoreshwa muri chimie organic nubuvuzi, cyane cyane mugutegura imiti itandukanye.

Nibikoresho byingenzi bya farumasi, aside shikimic irashobora gukoreshwa mukuvura indwara nyinshi ：

1. Antibacterial na antitumor

Mu 1987, intiti z'Abayapani zasanze ikigereranyo cya glyoxalase I inhibitor ikomatanyirijwe hamwe na methyl anthranilate igira ingaruka zigaragara ku murongo wa selile ya Hela na Escheri itera kanseri, bishobora kongera igihe cyo kubaho kw'imbeba zatewe na selile L1210, kandi uburozi bukaba buri hasi, Ingaruka zayo zo kubuza zifitanye isano ahanini na sulfure hydride reaction. 1988, intiti z’Abashinwa zifite Mu 1988, intiti z’Abashinwa zahujije inkomoko ya aside ya shikimike kandi zerekana ko iyi nteruro ifite ingaruka zo guhagarika ingirabuzimafatizo za L1210 muri vitro.

2. Kurwanya trombose

Ingaruka ya aside ya shikimic n'ibiyikomokaho kuri sisitemu yumutima nimiyoboro y'amaraso bigaragarira mu ruhare rwo kurwanya trombose no kubuza gukusanya platine. Ubushakashatsi bwerekana ko: acide ya shikimic igira ingaruka zikomeye zo kubuza igipimo cya platelet cyo guteranya kwa adenosine diphosphate iterwa na cerebral arterial embolism imbeba; inshinge zinjira mumitsi no mumitsi ya acide ya shikimic irashobora gutuma igihe cyo gutembera kumaraso cyimbeba zimara igihe kirekire.

3. Ischemia ya Anti-cerebral

Acide ya Shikimic n'ibiyikomokaho bifite ingaruka zo kunoza ischemie yubwonko, cyane cyane mukugabanya ingano yindwara yubwonko nyuma yibitekerezo byubwonko bwubwonko bwimbeba, kugabanya amanota yimikorere yubwonko, kugabanya urugero rwubwonko bwubwonko, kongera umuvuduko wamaraso wubwonko mukarere ka ischemic n'ibindi bipimo. Ubushakashatsi bumwe bwerekanye ko ibiyikomokaho bishobora kugabanya urugero rwo guteranya erythrocyte no kubuza kwishyira hamwe kwa platel nyuma yubwonko bwubwonko, bityo bikorohereza ubwonko bwubwonko.