Aside ya Shikimic ni iki?

Aside Shikimic (aside 3,4,5-trihydroxy-1-cyclohexene-1-carboxylic) ni ikintu kiboneka mu buryo busanzwe, kikaba ari ingenzi mu gukora lignin, aside amine zihumura neza (phenylalanine, tyrosine na tryptophan), hamwe na alkaloids nyinshi z’ibimera n’udukoko.

Aside Shikimic ikunze gukoreshwa nk'igikoresho cyo gutangira gukora umuti urwanya virusi witwa oseltamivir (umuti urwanya virusi ya H5N1 ikoreshwa mu kuvura no gukumira ubwoko bwose buzwi bwa virusi z'ibicurane). Byatangajwe ko gukora (-)-zeylenone ishingiye kuri aside Shikimic bikoreshwa cyane nk'umuti uvura kanseri. Amakuru araboneka ku gukora aside monopalmitoyloxy Shikimic, ifite ubushobozi bwo kurwanya amaraso kandi ishobora kugabanya amaraso agwa iyo itanzwe mu mitsi. Itsinda ry'abashakashatsi b'Abashinwa ryakoze aside Shikimic, triacetyl Shikimic, igaragaza ubushobozi bwo kurwanya amaraso agwa kandi irwanya thrombosis.

Byongeye kandi, ibikomoka kuri aside Shikimic byagaragaje ko bishishikajwe cyane n'ubuhinzi kuko byinshi muri byo bikoreshwa nk'imiti yica udukoko n'imiti irwanya udukoko kuko bishobora gufunga inzira ya aside Shikimic mu bimera na bagiteri bitagize ingaruka mbi ku nyamaswa.

Bityo, aside Shikimic ishobora gukoreshwa nk'ikintu gitera ingaruka mu guhuza ibinyabuzima haba mu bumenyi bw'ibanze ndetse no mu buvuzi mu butabire bw'ibinyabuzima ndetse no mu buvuzi, cyane cyane mu gutegura imiti itandukanye.

Nk'ikintu cy'ingenzi mu buvuzi, aside shikimic ishobora gukoreshwa mu kuvura indwara nyinshi:

1. Irwanya mikorobe n'indwara ya kanseri

Mu 1987, abahanga b'Abayapani basanze analoge ya glyoxalase I inhibitor ikorwa na methyl anthranilate ifite ingaruka zigaragara zo gukumira uturemangingo twa Hela na Escheri ascites carcinoma, ishobora kongera igihe cyo kubaho kw'imbeba zatewemo ingirabuzimafatizo za leukemia L1210, kandi uburozi ni buke, ingaruka zayo zo gukumira zifitanye isano ahanini n'uburyo sulfure hydride ikora. Mu 1988, abahanga b'Abashinwa babikoze Mu 1988, abahanga b'Abashinwa bakoze inkomoko ya aside shikimic kandi bagaragaje ko iyi mvange ifite ingaruka zo gukumira uturemangingo twa leukemia L1210 muri vitro.

2. Kurwanya thrombosis

Ingaruka za aside shikimic n'ibikomoka kuri yo ku mitsi y'umutima zigaragazwa mu rwego rwo kurwanya thrombosis no gukumira guteranya kwa platelets. Ubushakashatsi bwerekana ko: aside shikimic ifite ingaruka zikomeye ku muvuduko wo guteranya kwa platelets kw'imbeba ziterwa na adenosine diphosphate; gutera aside shikimic mu mitsi no mu mitsi bishobora gutuma igihe cyo guteranya amaraso mu mbeba kigabanuka.

3. Kurwanya ischemia yo mu bwonko

Aside Shikimic n'ibikomoka kuri yo bigira uruhare mu kunoza ischemia yo mu bwonko, cyane cyane mu kugabanya ingano y'indwara yo mu bwonko nyuma yo kubura amaraso mu bwonko mu mbeba, kugabanya amanota y'imikorere y'imitsi, kugabanya urugero rw'indwara yo kubura amaraso mu bwonko, kongera amaraso mu bwonko mu gace k'amaraso n'ibindi bimenyetso. Ubushakashatsi bumwe bwagaragaje ko ibikomoka kuri yo bishobora kugabanya urugero rw'iterana ry'amaraso mu bwonko no kubuza iterana ry'amaraso mu bwonko nyuma yo kubura amaraso mu bwonko, bityo bigafasha mu gutuma amaraso asohoka mu bwonko arushaho kumera neza.