Mu mpapuro ziheruka kuri iyi antioxydeant ikomeye harimo isubiramo ryasohotse mu bushakashatsi bwa Phytotherapy muri Werurwe 2019, ryasuzumye ingingo 9 zivuga ku ngaruka za quercetin kuri syndrome de metabolike Ikigereranyo cyagenzuwe.

Indwara ya metabolike isobanura urukurikirane rw'ibibazo by'ubuzima byongera ibyago byo kurwara diyabete yo mu bwoko bwa 2, indwara z'umutima, ndetse na stroke, harimo umuvuduko ukabije w'amaraso, isukari nyinshi mu maraso, urugero rwa triglyceride nyinshi, hamwe n'amavuta yo mu rukenyerero.

Nubwo ubushakashatsi bwimbitse bwerekanye ko quercetin nta ngaruka igira ku kwiyiriza ubusa glucose y’amaraso, kurwanya insuline cyangwa urwego rwa hemoglobine A1c, irindi sesengura ry’itsinda ryerekanye ko quercetin yongerewe mu bushakashatsi bwatwaye nibura mg 500 ku munsi byibura ibyumweru umunani. ”Kugabanya cyane isukari yamaraso yo kwiyiriza ubusa.

Quercetin ifasha kugenzura imvugo ya gene

Nk’uko ubushakashatsi bwashyizwe ahagaragara mu 2016 bubitangaza, quercetin irashobora kandi gukora umuyoboro wa mitochondial ya apoptose (progaramu ya selile yica selile yangiritse) ikorana na ADN, bityo bigatuma ibibyimba bisubira inyuma.

Ubushakashatsi bwerekanye ko quercetin ishobora gutera cytotoxicity ya selile leukemia, kandi ingaruka zijyanye na dose.Ingaruka nke za cytotoxic zabonetse no mu ngirangingo za kanseri y'ibere.Muri rusange, quercetin irashobora kongera igihe cyimbeba za kanseri inshuro 5 ugereranije nitsinda rishinzwe kutavurwa.

Abanditsi bavuga ko izo ngaruka ziterwa n’imikoranire itaziguye hagati ya quercetin na ADN no kuba ikora inzira ya mitochondrial inzira ya apoptose, kandi bavuga ko bishoboka ko ikoreshwa rya quercetin nk'umuti wifashisha mu kuvura kanseri bikwiye gukorwaho ubushakashatsi.

Ubushakashatsi buherutse gusohoka mu kinyamakuru Molecules bwashimangiye kandi ingaruka za epigenetike ya quercetin n'ubushobozi bwayo:

Imikoranire numuyoboro wibimenyetso bya selile
Tunganya imvugo ya gene
Gira ingaruka kubikorwa byo kwandukura
Igenga aside ya microribonucleic (microRNA)

Acide Microribonucleic yigeze gufatwa nka ADN "imyanda".Ubushakashatsi bwerekanye ko ADN “yubusa” ntacyo imaze.Mubyukuri ni molekile ntoya ya aside ya ribonucleic, igira uruhare runini mugutunganya ingirabuzimafatizo zikora poroteyine zabantu.

Acide Microribonucleic irashobora gukoreshwa nka "switch" yiyi genes.Ukurikije ibyinjijwe na acide ya microribonucleic, gene irashobora gushiramo ibicuruzwa byose birenga 200 bya poroteyine.Ubushobozi bwa Quercetin bwo guhindura microRNAs burashobora kandi gusobanura ingaruka za cytotoxic n'impamvu bisa nkaho byongera ubuzima bwa kanseri (byibuze ku mbeba).

Quercetin ni ikintu gikomeye kirwanya virusi

Nkuko byavuzwe haruguru, ubushakashatsi bwakozwe kuri quercetin bwibanze ku bushobozi bwabwo bwa virusi, buterwa ahanini nuburyo butatu bwo gukora:

Kubuza ubushobozi bwa virusi kwanduza selile
Kubuza kwigana ingirabuzimafatizo zanduye
Mugabanye kurwanya selile zanduye kuvura imiti igabanya ubukana

Kurugero, ubushakashatsi bwatewe inkunga na Minisiteri y’ingabo z’Amerika bwasohoye mu 2007 bwerekanye ko nyuma yo kugira ibibazo by’umubiri bikabije, quercetin ishobora kugabanya ibyago byo kwandura virusi no kunoza imikorere yawe yo mu mutwe, bitabaye ibyo ishobora kwangiza imikorere y’umubiri wawe, bigatuma ushobora kwandura cyane. n'indwara.

Muri ubu bushakashatsi, abanyamagare bakiriye mg 1000 za quercetin ku munsi, bakajyana na vitamine C (kongera urugero rwa plasma quercetin) na niacin (itera kwinjiza) mu byumweru bitanu bikurikiranye.Ibisubizo byagaragaye ko ugereranije no kutavurwa Ku mukinnyi wese wamagare wavuwe, abafashe quercetin bafite amahirwe make yo kwandura indwara ya virusi nyuma yo gutwara igare amasaha atatu kumunsi iminsi itatu ikurikiranye.45% by'abantu bari mu itsinda rya placebo bari barwaye, mu gihe 5% gusa by'abantu bari mu itsinda rivura bari barwaye.

Ikigo cy’Amerika gishinzwe guteza imbere ubushakashatsi bw’ubushakashatsi (DARPA) cyateye inkunga ubundi bushakashatsi bwasohowe mu 2008, kandi bwiga ku ikoreshwa rya virusi ya grippe H1N1 yanduye cyane kugira ngo ihangane n’inyamaswa zivurwa na quercetine.Igisubizo kiracyari kimwe, uburwayi nimpfu zitsinda ryivura byari hasi cyane ugereranije nitsinda rya placebo.Ubundi bushakashatsi nabwo bwemeje imikorere ya quercetin irwanya virusi zitandukanye, harimo:

Ubushakashatsi bwakozwe mu 1985 bwerekanye ko quercetin ishobora guhagarika kwandura no kwigana virusi ya herpes simplex yo mu bwoko bwa 1, ubwoko bwa poliovirus yo mu bwoko bwa 1, virusi ya parainfluenza yo mu bwoko bwa 3, na virusi ya syncytial respiratory.

Ubushakashatsi bw’inyamaswa mu mwaka wa 2010 bwerekanye ko quercetin ishobora guhagarika virusi ya grippe A na B.Hariho kandi ibintu bibiri byingenzi byavumbuwe.Ubwa mbere, izo virusi ntizishobora guteza imbere kurwanya quercetin;icya kabiri, niba zikoreshwa zifatanije nibiyobyabwenge bya virusi (amantadine cyangwa oseltamivir), ingaruka zazo ziyongera cyane-kandi iterambere ryokurwanya rirakumirwa.

Ubushakashatsi bw’inyamaswa mu 2004 bwemeje virusi ya H3N2, ikora iperereza ku ngaruka za quercetin kuri ibicurane.Umwanditsi yerekanye ati:

"Mu gihe cyo kwandura virusi ya grippe, guhangayika kwa okiside. Kubera ko quercetin ishobora kugarura imbaraga za antioxydants nyinshi, abantu bamwe batekereza ko ishobora kuba imiti ikomeye ishobora kurinda ibihaha kurekurwa mu gihe cyanduye virusi. "

Ubundi bushakashatsi bwakozwe mu 2016 bwerekanye ko quercetin ishobora kugenga imvugo ya poroteyine kandi ikagira ingaruka zo gukingira virusi ya grippe H1N1.By'umwihariko, kugena poroteyine yubushyuhe, fibronectine 1 na proteyine yo kubuza bifasha kugabanya virusi.

Ubushakashatsi bwa gatatu bwasohotse mu 2016 bwerekanye ko quercetin ishobora guhagarika ibicurane bitandukanye, harimo H1N1, H3N2, na H5N1.Umwanditsi wa raporo y’ubushakashatsi yizera ati: “Ubu bushakashatsi bwerekana ko quercetin igaragaza ibikorwa bibuza abantu hakiri kare kwandura ibicurane, bitanga gahunda ishoboka yo kuvura ejo hazaza hifashishijwe imiti gakondo, itekanye, kandi ihendutse yo kuvura no gukumira [ibicurane Virusi] kwandura. "

Mu mwaka wa 2014, abashakashatsi bagaragaje ko quercetin “isa naho itanga icyizere mu kuvura ibicurane bisanzwe biterwa na rhinovirus” maze bongeraho bati: “Ubushakashatsi bwemeje ko quercetin ishobora kugabanya kwinjiza no kwigana virusi muri vitro.Umubiri urashobora kugabanya umutwaro wa virusi, umusonga hamwe na hyperresponsiveness yo mu kirere. "

Quercetin irashobora kandi kugabanya kwangirika kwa okiside, bityo bikagabanya ibyago byo kwandura bagiteri ya kabiri, ari nayo mpamvu nyamukuru itera impfu ziterwa na grippe.Icy'ingenzi, quercetin yongerera mitochondrial biosynthesis mumitsi ya skeletale, byerekana ko igice cyingaruka zayo ziterwa na virusi biterwa nikimenyetso cya virusi ya mitochondial.

Ubushakashatsi bw’inyamaswa mu 2016 bwerekanye ko quercetin ishobora guhagarika virusi ya dengue na virusi ya hepatite mu mbeba.Ubundi bushakashatsi nabwo bwemeje ko quercetin ifite ubushobozi bwo guhagarika indwara ya hepatite B na C.

Vuba aha, ubushakashatsi bwasohotse mu kinyamakuru Microbial Pathogenesis muri Werurwe 2020 bwerekanye ko quercetin ishobora kurinda byimazeyo kwandura Streptococcus pneumoniae haba muri vitro ndetse no muri vivo.Uburozi (PLY) bwarekuwe na pneumococcus kugirango birinde icyorezo cya Streptococcus pneumoniae.Muri raporo "Microbial Pathogenesis", umwanditsi yerekanye:

"Ibisubizo byerekana ko quercetin igabanya cyane ibikorwa bya hemolytic na cytotoxicity iterwa na PLY mu kubuza ishyirwaho rya oligomers.
Byongeye kandi, kuvura quercetin birashobora kandi kugabanya kwangirika kwingirabuzimafatizo ya PLY, kongera ubuzima bwimbeba zanduye dosiye zica pneumoniae ya Streptococcus, kugabanya kwangirika kw ibihaha, no kubuza cytokine (IL-1β na TNF) mumazi ya bronchoalveolar.-α) kurekura.
Twihweje akamaro k'ibi bintu mu gutera indwara ya Streptococcus pneumoniae irwanya, ibisubizo byacu byerekana ko quercetin ishobora kuba umukandida mushya w’ibiyobyabwenge mu kuvura indwara zandurira mu mitsi."
Quercetin irwanya gucana kandi ikongera imikorere yumubiri

Usibye ibikorwa bya virusi, quercetin irashobora kandi kongera ubudahangarwa no kurwanya umuriro.Ubushakashatsi bwakozwe mu mwaka wa 2016 bwasohotse mu kinyamakuru Nutrients bwerekanye ko uburyo bwo gukora burimo (ariko ntibugarukira gusa) kubuza:

• Tumor necrosis factor alpha (TNF-α) iterwa na lipopolysaccharide (LPS) muri macrophage.TNF-α ni cytokine igira uruhare mu gutwika sisitemu.Irekurwa na macrophage ikora.Macrophage ni selile yumubiri ishobora kumira ibintu byamahanga, mikorobe nibindi bintu byangiza cyangwa byangiritse.
• Lipopolysaccharide iterwa na TNF-α na interleukin (Il) -1α mRNA mu tugingo ngengabuzima, ibyo bikaba bishobora gutuma "kugabanuka kwa apoptose selile".
• Kubuza kubyara imisemburo itera umuriro
• Irinde calcium gutembera mu ngirabuzimafatizo, bityo bikabuza:
Kurekura cytokine itera umuriro
Cell Ingirabuzimafatizo zo mu nda zirekura histamine na serotonine 

Nk’uko iyi ngingo ibivuga, quercetin irashobora kandi guhagarika ingirabuzimafatizo, ikagira ibikorwa bya cytoprotective ku nzira ya gastrointestinal, kandi "ikagira ingaruka zitaziguye ku mikorere y’ibanze y’imikorere y’uturemangingo", ku buryo ishobora "kugabanya-kugenzura cyangwa kubuza ibintu bitandukanye. imiyoboro n'imikorere, "Kubuza umubare munini w'intego za molekile mu ntera ya micromolar".

Quercetin irashobora kuba inyongera yingirakamaro kubantu benshi

Urebye inyungu nyinshi za quercetin, irashobora kuba inyongera yingirakamaro kubantu benshi, yaba ibibazo bikaze cyangwa birebire, birashobora kugira ingaruka runaka.Iyi ninyongera ndagusaba ko wagumana muri kabine yimiti.Irashobora gukenerwa mugihe wumva ko ugiye "kurengerwa" nikibazo cyubuzima (cyaba ubukonje cyangwa ibicurane bisanzwe).

Niba ukunda gufata ibicurane n'ibicurane, ushobora gutekereza gufata quercetin amezi make mbere yubukonje nibicurane kugirango ukomeze umubiri wawe.Mugihe kirekire, bisa nkaho ari ingirakamaro cyane kubarwayi barwaye syndrome de metabolike, ariko ni ibicucu cyane kwishingikiriza gusa ku nyongeramusaruro zimwe na zimwe no kunanirwa gukemura ibibazo by'ibanze nk'imirire n'imyitozo icyarimwe.