Mu nyandiko ziheruka kuri iyi antioxydant ikomeye harimo isuzuma ryasohotse mu bushakashatsi bwa Phytotherapy muri Werurwe 2019, ryasuzumye ingingo 9 ku ngaruka za quercetin ku ndwara ya metabolic. Igerageza ryakozwe ku buryo bwa Randomized controlled.

Indwara ya metabolike yerekeza ku bibazo by’ubuzima byongera ibyago byo kurwara diyabete yo mu bwoko bwa 2, indwara z’umutima, no gucika imitsi, harimo umuvuduko ukabije w’amaraso, isukari nyinshi mu maraso, urugero rwa triglyceride nyinshi, n’ibinure byiyongera mu rukenyerero.

Nubwo ubushakashatsi bwuzuye bwagaragaje ko quercetin nta ngaruka igira ku isukari yo mu maraso ikora mu buryo bwo kwiyiriza ubusa, ubudahangarwa bwa insuline cyangwa urugero rwa hemoglobine A1c, ubundi bushakashatsi bwerekanye ko quercetin yongerewe mu bushakashatsi bwafashe nibura miligarama 500 ku munsi mu gihe cy'ibyumweru umunani.” Isukari yo mu maraso ikora mu buryo bwo kwiyiriza ubusa yagabanutse cyane.

Quercetin ifasha mu kugenzura igaragara ry'uturemangingo

Dukurikije ubushakashatsi bwasohotse mu 2016, quercetin ishobora kandi gukora umuyoboro wa mitochondrial wa apoptosis (urupfu rw’uturemangingo twangiritse) binyuze mu gukorana na ADN, bityo bigatuma ikibyimba gisubira inyuma.

Ubushakashatsi bwagaragaje ko quercetin ishobora gutera uburozi bw’uturemangingo twa kanseri y’amaraso, kandi ingaruka zayo zifitanye isano n’ingano y’umuti. Ingaruka nke zagaragaye mu turemangingo twa kanseri y’ibere. Muri rusange, quercetin ishobora kongera igihe cyo kubaho cy’imbeba za kanseri inshuro 5 ugereranije n’itsinda ry’abayirwanya ritavuwe.

Abanditsi bavuga ko izi ngaruka ziterwa n’imikoranire itaziguye hagati ya quercetin na ADN no gukora kwayo inzira ya mitochondrial ya apoptosis, kandi bavuga ko gukoresha quercetin nk'umuti wunganira mu kuvura kanseri bikwiye gukorerwa ubushakashatsi bwimbitse.

Ubushakashatsi buherutse gusohoka mu kinyamakuru Molecules bwashimangiye ingaruka za quercetin ku ihinduka ry’uturemangingo (epigenetic) n’ubushobozi bwayo bwo:

Uburyo bwo gukorana n'imiyoboro y'amakuru y'uturemangingo
Kugenzura igaragara ry'uturemangingo
Ingaruka ku bikorwa by'ibintu byanditse
Igenzura aside mikororibonucleique (microRNA)

Aside mikororibonucleique yigeze gufatwa nka ADN "imyanda". Ubushakashatsi bwagaragaje ko ADN "imyanda" ntacyo imaze. Mu by'ukuri ni molekile nto ya aside ribonucleique, igira uruhare runini mu kugenzura utunyangingo dukora poroteyine z'abantu.

Aside ya microribonucleic ishobora gukoreshwa nk'"ihindura" izi gene. Dukurikije uko aside microribonucleic ibyinjira, gene ishobora kwandika poroteyine imwe mu zirenga 200. Ubushobozi bwa Quercetin bwo guhindura microRNA bushobora kandi gusobanura ingaruka zayo zo kwangiza imikorere y'uturemangingo n'impamvu isa n'aho yongera ubuzima bwa kanseri (byibura ku mbeba).

Quercetin ni ikintu gikomeye gifasha mu kurwanya indwara ziterwa n'imiti

Nkuko byavuzwe haruguru, ubushakashatsi bwakozwe kuri quercetin bwibanda ku bushobozi bwayo bwo kurwanya virusi, ahanini buterwa n'uburyo butatu bukoreshwamo:

Kubuza virusi ubushobozi bwo kwanduza uturemangingo
Kubuza ko uturemangingo twanduye twongera kwiyongera
Kugabanya ubudahangarwa bw'uturemangingo twanduye ku miti igabanya ubukana bw'imiti igabanya ubukana bw'udukoko

Urugero, ubushakashatsi bwatewe inkunga na Minisiteri y’Ingabo ya Amerika bwasohotse mu 2007 bwagaragaje ko nyuma yo kugira stress ikomeye ku mubiri, quercetin ishobora kugabanya ibyago byo kwandura virusi no kunoza imikorere y’ubwonko bwawe, bitabaye ibyo ishobora kwangiza imikorere y’ubudahangarwa bw’umubiri wawe, bigatuma urushaho kwibasirwa n’indwara.

Muri ubu bushakashatsi, abanyamagare bahawe mg 1000 za quercetin ku munsi, hamwe na vitamine C (iyongera urugero rwa quercetin mu maraso) na niacin (ituma umuntu yinjizwa mu mubiri) mu byumweru bitanu bikurikirana. Ibisubizo byagaragaje ko ugereranije n’abatavuwe. Ku muntu wese utwara igare wavuwe, abafashe quercetin bari bafite amahirwe make cyane yo kwandura indwara ya virusi nyuma yo kugenda ku igare amasaha atatu ku munsi mu minsi itatu yikurikiranya. 45% by’abantu bo mu itsinda rya placebo bari barwaye, mu gihe 5% gusa by’abantu bo mu itsinda ryavuwe ari bo barwaye.

Ikigo cy’Ubushakashatsi ku Mishinga y’Ubushakashatsi ku Ngabo za Amerika (DARPA) cyateye inkunga ubundi bushakashatsi, bwasohotse mu 2008, kandi bwiga ku ikoreshwa rya virusi ya grippe H1N1 itera indwara nyinshi mu kurwanya inyamaswa zavuwe na quercetin. Ibisubizo biracyari bimwe, indwara n’impfu by’itsinda ryavuwe byari bike cyane ugereranyije n’itsinda rya placebo. Ubundi bushakashatsi bwemeje kandi ko quercetin ikora neza mu kurwanya virusi zitandukanye, harimo:

Ubushakashatsi bwakozwe mu 1985 bwagaragaje ko quercetin ishobora gukumira ubwandu no kwiyongera kwa virusi ya herpes simplex yo mu bwoko bwa 1, virusi ya polio yo mu bwoko bwa 1, virusi ya parainfluenza yo mu bwoko bwa 3, na virusi itera ubuhumekero.

Ubushakashatsi bwakozwe ku nyamaswa mu 2010 bwagaragaje ko quercetin ishobora gukumira virusi zombi za grippe A na B. Hari kandi ibintu bibiri by'ingenzi byavumbuwe. Icya mbere, izi virusi ntizishobora kugira ubudahangarwa kuri quercetin; icya kabiri, iyo zikoreshejwe hamwe n'imiti igabanya ubukana (amantadine cyangwa oseltamivir), ingaruka zazo zirushaho kwiyongera - kandi iterambere ry'ubudahangarwa rikaburindwa.

Inyigo y’inyamaswa mu 2004 yemeje ubwoko bwa virusi ya H3N2, ikora ubushakashatsi ku ngaruka za quercetin ku bicurane. Umwanditsi yagaragaje:

"Mu gihe cy'ubwandu bwa virusi ya grippe, habaho stress ya oxidative. Kubera ko quercetin ishobora kugarura ubwinshi bwa antioxydants nyinshi, hari abantu batekereza ko ishobora kuba umuti mwiza ushobora kurinda ibihaha kurekurwa mu gihe cy'ubwandu bwa virusi ya grippe. Ingaruka mbi za radicals zidafite ogisijeni."

Ubundi bushakashatsi bwo mu 2016 bwagaragaje ko quercetin ishobora kugenzura ikoreshwa rya poroteyine kandi ikagira ingaruka ku icyorezo cya grippe H1N1. By’umwihariko, kugenzura poroteyine itera ubushyuhe, fibronectin 1 na poroteyine ibuza indwara bifasha kugabanya ukwiyongera kwa virusi.

Ubushakashatsi bwa gatatu bwasohotse mu 2016 bwagaragaje ko quercetin ishobora gukumira ubwoko butandukanye bw'ibicurane, harimo H1N1, H3N2, na H5N1. Umwanditsi w'iyi raporo y'ubushakashatsi yizera ko “Ubu bushakashatsi bwerekana ko quercetin igira uruhare mu gukumira indwara mu ntangiriro z'ubwandu bw'ibicurane, butanga gahunda ishoboka yo kuvura mu gihe kizaza binyuze mu guteza imbere imiti karemano ikora neza, yizewe kandi ihendutse yo kuvura no gukumira ubwandu [bwa virusi ya Grippe A].”

Mu 2014, abashakashatsi bagaragaje ko quercetin “isa n’aho ifite icyizere mu kuvura ibicurane bikunze guterwa na virusi z’inkura” bongeraho bati: “Ubushakashatsi bwemeje ko quercetin ishobora kugabanya kwinjira no kwiyongera kwa virusi mu mubiri. Umubiri ushobora kugabanya umubare wa virusi, umusonga no kugira ingaruka mbi ku miyoboro y’umwuka.”

Quercetin ishobora kandi kugabanya kwangirika kwa ogisijeni, bityo ikagabanya ibyago byo kwandura bagiteri za kabiri, ari na zo mpamvu nyamukuru y’impfu ziterwa na grippe. Icy'ingenzi ni uko quercetin yongera imikorere ya mitochondria mu mitsi y’amagufwa, bigaragaza ko igice cy’ingaruka zayo zo kurwanya virusi biterwa n’uko mitochondria irushaho kuba nziza.

Ubushakashatsi bwakozwe ku nyamaswa mu 2016 bwagaragaje ko quercetin ishobora gukumira virusi ya dengue n'ubwandu bwa virusi ya hepatite mu mbeba. Ubundi bushakashatsi bwemeje kandi ko quercetin ifite ubushobozi bwo gukumira ubwandu bwa hepatite B na C.

Vuba aha, ubushakashatsi bwasohotse mu kinyamakuru Microbial Pathogenesis muri Werurwe 2020 bwagaragaje ko quercetin ishobora gutanga uburinzi bwuzuye ku bwandu bwa Streptococcus pneumoniae haba mu buryo bwa vitro ndetse no mu mubiri. Uburozi (PLY) buva muri pneumococcus kugira ngo hirindwe icyorezo cya Streptococcus pneumoniae. Muri raporo "Pathogenesis ya Microbial", umwanditsi yagaragaje:

"Ibisubizo bigaragaza ko quercetin igabanya cyane imikorere y'amaraso mu mubiri n'uburozi buterwa na PLY binyuze mu kubuza ikorwa rya oligomer."
Byongeye kandi, kuvura quercetin bishobora kandi kugabanya kwangirika kw'uturemangingo duterwa na PLY, kongera igihe cyo kubaho kw'imbeba zanduye doze yica ya Streptococcus pneumoniae, kugabanya kwangirika kw'ibihaha, no gukumira cytokines (IL-1β na TNF) mu gusohora amazi yo mu bwonko. -α).
Ukurikije akamaro k'ibi bintu mu gutera indwara ya Streptococcus pneumoniae idakira, ibisubizo byacu bigaragaza ko quercetin ishobora kuba umuti mushya ushobora gukoreshwa mu kuvura indwara zandura za pneumococcal.
Quercetin irwanya ububyimbirwe kandi ikongera imikorere y'ubudahangarwa bw'umubiri

Uretse kuba irwanya virusi, quercetin ishobora no kongera ubudahangarwa bw'umubiri no kurwanya ububyimbirwe. Ubushakashatsi bwakozwe mu 2016 bwasohotse mu kinyamakuru Nutrients bwagaragaje ko uburyo bwo gukora ibintu burimo (ariko ntibugarukira gusa ku) gukumira:

• Tumor necrosis factor alpha (TNF-α) iterwa na lipopolysaccharide (LPS) muri macrophages. TNF-α ni cytokine igira uruhare mu kubyimba kw'umubiri. Ituruka muri macrophages ikora. Macrophages ni uturemangingo tw'ubudahangarwa dushobora kumira ibintu by'amahanga, mikorobe n'ibindi bintu byangiza cyangwa byangiritse.
• Urugero rwa TNF-α na interleukin (Il)-1α mRNA ruterwa na lipopolysaccharide mu turemangingo twa glial, bishobora gutuma "apoptosis y'uturemangingo tw'imitsi igenda igabanuka"
• Kubuza ikorwa rya enzymes zitera ububyimbirwe
• Kubuza kalisiyumu kwinjira mu turemangingo, bityo bikabuza:
◦ Irekurwa rya cytokines zitera ububabare
◦ Uturemangingo tw’amara dusohora histamine na serotonin 

Dukurikije iyi ngingo, quercetin ishobora kandi gutuma uturemangingo twa mast tuguma neza, ikagira imikorere yo kurinda indwara mu gifu, kandi "ikagira ingaruka ku mikorere y'ibanze y'uturemangingo tw'ubudahangarwa", ku buryo ishobora "kugabanya cyangwa gukumira inzira zitandukanye z'ububyimbirwe n'imikorere yabyo," ikabuza umubare munini w'ibintu bitera uburozi mu rugero rwa micromolar concentration".

Quercetin ishobora kuba inyongeramusaruro y'ingirakamaro ku bantu benshi

Ukurikije ibyiza byinshi bya quercetin, ishobora kuba inyongeramusaruro ku bantu benshi, byaba ari ibibazo bikomeye cyangwa iby'igihe kirekire, ishobora kugira ingaruka runaka. Iyi ni inyongeramusaruro nsaba ko wayibika mu kabati k'imiti. Ishobora kugufasha mu gihe wumva ko ugiye "guhangayikishwa" n'ikibazo cy'ubuzima (cyaba ari ibicurane cyangwa grippe).

Niba ukunze gufatwa n'ibicurane n'inkorora, ushobora gutekereza gufata quercetin amezi make mbere y'igihe cy'ibicurane n'inkorora kugira ngo wongere ubudahangarwa bw'umubiri wawe. Mu gihe kirekire, bisa nkaho ari ingirakamaro cyane ku barwayi bafite indwara ya metabolike, ariko ni ubupfapfa cyane kwishingikiriza gusa ku nyongeramusaruro zimwe na zimwe ukananirwa gukemura ibibazo by'ibanze nko kurya no gukora imyitozo ngororamubiri icyarimwe.