Kanseri y'ibihaha ni ubwoko bwa kabiri bwa kanseri ikunze kugaragara ku isi. Muri 2020, abantu barenga miliyoni 2.2 kwisi yose bazasuzumwa kanseri yibihaha kunshuro yambere. Muri uwo mwaka, abantu bagera kuri miliyoni 1.8 ku isi bapfuye bazize kanseri y'ibihaha.
Mugihe kuri ubu nta muti wa kanseri y'ibihaha, abahanga barimo gukora uburyo bwo kuvura. Bamwe muri aba bahanga bakorera muri kaminuza y’ikoranabuhanga ya Sydney (UTS), aho ubushakashatsi bushya bwerekanye ko uruganda rusanzwe rw’ibimera rwitwa berberine rushobora guhagarika imikurire ya kanseri y'ibihaha muri laboratoire.
Berberine ni ibimera bisanzwe biboneka byakoreshejwe mubuvuzi gakondo bwabashinwa mumyaka ibihumbi. Iboneka mu bimera bitandukanye, birimo barberry, goldenseal, imizabibu ya Oregon, hamwe na turmeric.

(Ibicuruzwa byacu niBerberine, twakiriye neza kubaza.)

Imyaka myinshi y'ubushakashatsi yerekanye ko berberine igira akamaro mu gufasha abantu barwaye diyabete yo mu bwoko bwa 2 kugenga urugero rw'isukari mu maraso kandi bishobora gufasha kuvura syndrome de metabolike.
Abashakashatsi basanze kandi berberine ishobora gukoreshwa mu kuvura kanseri zitandukanye, harimo intanga ngore, igifu, na kanseri y'ibere.
Nk’uko byatangajwe na Dr. Kamal Dua, Umwarimu Ukomeye akaba n'Umushakashatsi Ukomeye muri Farumasi mu kigo cy’ubushakashatsi cya Ositarariya gishinzwe ubuvuzi bwuzuye kandi bwuzuye (ARCCIM), Ishuri Rikuru ry’Ubuvuzi rya kaminuza y’ikoranabuhanga Sydney (UTS) akaba n’umwanditsi w’ubushakashatsi, Berberine abuza urufunguzo ebyiri inzira mu iterambere rya kanseri - Gukwirakwiza no kwimuka kwa selile.
Ati: "Muburyo bwa tekinike, ibi birashobora kugerwaho muguhagarika ingirabuzimafatizo nka P53, PTEN na KRT18 na proteyine nka AXL, CA9, ENO2, HER1, HER2, HER3, PRGN, PDGF-AA, DKK1, CTSB, CTSD, BCLX, CSF1. na CAPG bifitanye isano no gukwirakwiza no kwimuka kwa kanseri ya kanseri ”.
Muri ubu bushakashatsi, itsinda ry’ubushakashatsi ririmo Dr. Dua, Dr. Keshav Raj Paudel, Porofeseri Philip M. Hansbrough na Dr. Bikash Manandhar wo muri UTS, ndetse n’abakozi bo muri kaminuza mpuzamahanga y’ubuvuzi ya Maleziya na kaminuza ya Al Qasim muri Arabiya Sawudite, yize uburyo berberine ishobora gukoreshwa mu kuvura kanseri y'ibihaha.
Dr. Dua muri MNT yabisobanuye agira ati: "Gukoresha ivuriro rya berberine ni bike kubera kutagira ubushobozi buke ndetse na bioavailable". Ati: “Intego nyamukuru y'ubu bushakashatsi ni ugutezimbere ibipimo bya fiziki ya chimique ya berberine uhindura berberine mu mazi ya kirisitu ya kirisitu no gushakisha ubushobozi bwayo bwa anticancer muri vitro kuri selire ya alveolar epithelial selile ya adenocarcinoma A549.”
Itsinda ry’ubushakashatsi ryashyizeho uburyo bunoze bwo gutanga ibiyobyabwenge bikubiyemo berberine mu tuntu duto duto kandi twangiza ibinyabuzima. Aya mavuta ya kirisiti ya nanoparticles yakoreshejwe mu kuvura kanseri y'ibihaha ya muntu muri vitro muri laboratoire.
Ubushakashatsi burangiye, itsinda ryasanze berberine yafashije mu guhagarika umusaruro w’ubwoko bwa ogisijeni ikora, imiti yica umuriro ikorwa na selile zimwe na zimwe mu rwego rwo guhangana na bagiteri ndetse n’ibindi bintu bitesha umutwe bishobora kwangiza selile.
Byongeye kandi, berberine ifasha kugenga ingirabuzimafatizo zijyanye na stress ya okiside ndetse no gutwika, kandi ifasha kugabanya gusaza imburagihe.
Dr. Dua yabisobanuye agira ati: “Twerekanye ko, dukoresheje uburyo bwa nanotehnologiya, imitungo y'uru ruganda ishobora kunozwa kugira ngo ikemure ibibazo bitandukanye bijyanye no gukemuka, gufata selile, ndetse no kuvura neza.” Anticancer Potential Berberine yamazi ya kirisiti ya kirisitu yerekanaga ibikorwa bimwe inshuro eshanu ikigereranyo ugereranije nubuvanganzo bwasohotse, byerekana neza inyungu za nanodrugs. ”
Kugirango arusheho gusuzuma ibi bisubizo, Dr. Dua yavuze ko ateganya gukoresha urubuga rushya rw’ubushakashatsi kugira ngo akore ubushakashatsi bwimbitse akoresheje icyitegererezo cy’inyamaswa za kanseri y'ibihaha.
Yabisobanuye agira ati: "Ubundi bushakashatsi bwa farumasi na anticancer bwakozwe na berberine nanodrugs mu bwoko bw’inyamanswa muri vivo bushobora kwerekana inyungu zishobora kuvurwa mu kuvura kanseri y'ibihaha no kuyihindura uburyo bwo kuvura."
Dr. Dua yagize ati: "Nitumara kwemeza ubushobozi bwo kurwanya kanseri ya berberine nanodrugs mu buryo bw'inyamanswa z’inyamanswa, intambwe ikurikira izaba iyo kwimukira mu mavuriro, dusanzwe tuganira n'ibigo byinshi bya Sydney."
Byongeye kandi, Dr. Dua yavuze ko hagomba kwemezwa ko ubushobozi bwa berberine bwo kwirinda kanseri y'ibihaha itazongera kubaho: “Nubwo tutarabikoraho iperereza, turateganya kubyiga mu bushakashatsi buzaza, kandi twizera ko nanoforms ya berberine izerekana ibikorwa bitanga icyizere. “.
Dr. Osita Onuga, umuganga ubaga thoracic akaba n'umwarimu wungirije w’ubuvuzi bwa thoracic mu kigo cy’ubuvuzi cya kanseri cyitiriwe Mutagatifu Yohani mu kigo cy’ubuvuzi cya Providence St. ibyiringiro:
Ati: “Berberine iri mu buvuzi bwo mu Burasirazuba, ntabwo rero dusanzwe tuyikoresha mu buvuzi bwo mu Burengerazuba. Nibwira ko bishimishije kuko turimo kureba ibyo tuzi bifite inyungu kubintu byubuvuzi bwiburasirazuba, kandi tubishyira mubushakashatsi kugirango bifashe kubisobanura mubuvuzi bwiburengerazuba. “.
Onuga yakomeje agira ati: "Buri gihe biratanga icyizere, ariko biri muri laboratoire, kandi byinshi mu byo dusanga muri laboratoire ntabwo byanze bikunze bituma abarwayi bavurwa." Ati: “Ntekereza ko igikurikira gukora ari ugukora ibizamini byo kwa muganga ku barwayi no kumenya urugero.”
Abantu bamwe bagaragaza ibimenyetso byoroshye bya kanseri yibihaha mugihe cyambere cyindwara. Soma kugirango wige byinshi, harimo nigihe cyo kubonana na muganga.
Kanseri y'ibihaha ibaho ku bipimo bitandukanye ku bagore no ku bagabo, ariko ibimenyetso n'ingaruka ni zimwe. Hano turasobanura ibishoboka genetike na hormone…
Turi uruganda rukora ibimera bivamo ifu, urakaza neza kohereza ibibazo byawe kubyerekeye ibicuruzwa byacu kandi dufite mugenzi dukorana kugirango akemure ibibazo byawe mbere yo kugurisha na nyuma yo kugurisha. Twandikire Igihe icyo aricyo cyose !!!