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Mu bushakashatsi buherutse gusohoka mu kinyamakuru Pharmaceutics, abashakashatsi bagaragaje ko umuti w’ibimera witwa FRO urwanya indwara ziterwa n’ibiheri.
Isuzuma ry’imiti irwanya udukoko ndetse n’isesengura ryakozwe mu buryo bwa vitro byagaragaje ko FRO ifite ingaruka zikomeye ku mikorobe no kurwanya ububyimbirwe kuri Dermatobacillus Acnes (CA), bagiteri itera ibiheri. Ibi bisubizo bigaragaza ko ikoreshwa neza kandi karemano mu kuvura ibiheri, bishyigikira ikoreshwa ry’ubundi buryo butari uburozi kandi buhendutse bwo gukoresha imiti ikoreshwa ubu isanzwe ivura ibiheri.
Ubushakashatsi: Ingufu za FRO mu gutera ibiheri by'uburozi. Ishusho yatanzwe na: Steve Jungs / Shutterstock.com
Indwara y'uruhu ikunze kugaragara iterwa n'udusatsi tw'umusatsi dufunganye hamwe n'uturemangingo tw'uruhu twapfuye. Indwara y'uruhu ifata abangavu barenga 80%, nubwo idahitana, ishobora gutera ibibazo byo mu mutwe, mu bihe bikomeye, ibara ry'uruhu rihoraho n'inkovu.
Ibiheri bituruka ku mikoranire y’ibintu bigize imiterere y’umubiri n’ibidukikije, akenshi bigaterwa n’impinduka mu misemburo zijyana n’ubugimbi mu gihe cy’ubugimbi. Uku kutumvikana kw’imisemburo byongera umusaruro wa sebum kandi byongera imikorere ya insuline 1 (IGF-1) na dihydrotestosterone (DHT).
Kwiyongera kw'ibinure bifatwa nk'intambwe ya mbere mu gutera ibiheri, kubera ko uduce tw'umusatsi twuzuyemo ibinure tubamo udukoko twinshi nka SA. SA ni ikintu gisanzwe cy'uruhu; icyakora, kwiyongera kw'ubwoko bwa IA1 bitera kubyimba no guhinduka kw'ibinure by'umusatsi hamwe n'udupfukamunwa tugaragara inyuma.
Hari uburyo butandukanye bwo kuvura ibiheri, nka retinoids n'imiti ikoreshwa mu kuvura udukoko, ikoreshwa hamwe n'ibishishwa bya shimi, ubuvuzi bwa laser/light, n'imiti ikoreshwa mu misemburo. Ariko, ubu buryo burahenze kandi bufitanye isano n'ingaruka mbi.
Ubushakashatsi bwakozwe mbere bwagaragaje ibikomoka ku bimera nk'uburyo buhendutse kandi buhendutse bwo kuvura. Nk'ubundi buryo, ibikomoka kuri Rhus vulgaris (RV) byizweho. Ariko, ikoreshwa ryabyo rigengwa n'urushiol, igice cy'ingenzi cy'iki giti gitera ubwivumbure.
FRO ni formula y'ibimera irimo ibinyabutabire bya RV (FRV) na mangosteen y'Abayapani (OJ) ku gipimo cya 1: 1. Ingufu z'iyo formula zageragejwe hakoreshejwe ibizamini byakozwe muri vitro n'ubushobozi bwo kurwanya mikorobe.
Uruvange rwa FRO rwabanje kugaragazwa hakoreshejwe chromatography y’amazi ifite ubushobozi bwo hejuru (HPLC) kugira ngo hamenyekane, hamenyekane kandi hamenyekane ibice bigize uru ruvange. Uruvange rwakomeje gusesengurwa kugira ngo hamenyekane ingano y’ibinyabutabire byose (TPC) kugira ngo hamenyekane ibintu bishobora kugira ubushobozi bwo kurwanya mikorobe.
Isuzuma rya mbere ryakozwe hifashishijwe imiti yica udukoko mu buryo bwa "in vitro" hasuzumwa uburyo bwo gukwirakwiza udukoko mu buryo bwa "disk". Ubwa mbere, CA (phylotype IA1) yatewe ku gipande cy'agahu gakozwe mu buryo bumwe, aho hashyizwemo agapapuro k'urupapuro ka FRO gafite umurambararo wa mm 10. Imikorere ya antibiyotike yapimwe hapimwa ingano y'agace kayirinda.
Uburyo FRO ikora ku ikorwa rya sebum iterwa na CA ndetse no kwiyongera kwa androgen bifitanye isano na DHT byapimwe hakoreshejwe isesengura rya Oil Red staining na Western blot, uko bikurikirana. Nyuma FRO yapimwe ubushobozi bwayo bwo kugabanya ingaruka za reactive oxygen species (ROS), zituma habaho hyperpigmentation ifitanye isano n'ibiheri n'inkovu nyuma yo kubagwa, hakoreshejwe probe ya 2′,7′-dichlorofluorescein diacetate (DCF-DA).
Ibisubizo by'igerageza ryo gukwirakwiza disiki byagaragaje ko 20 μL bya FRO byabujije gukura kwa CA neza kandi bigatanga agace kagaragara ko kabuzanya uburebure bwa mm 13 ku gipimo cya 100 mg / mL. FRO igabanya cyane ukwiyongera kw'isohoka rya sebum riterwa na SA, bityo bigagabanya cyangwa bigasubiza inyuma kugaragara kw'ibiheri.
Byagaragaye ko FRO ikungahaye ku bintu bya phenolic birimo aside gallic, kaempferol, quercetin na fisetin. Igipimo cy’ibinyabutabire bya phenolic (TPC) cyanganaga na 118.2 mg ya aside gallic equivalents (GAE) kuri garama imwe FRO.
FRO yagabanyije cyane ububyimbirwe bw'uturemangingo buterwa na ROS iterwa na SA ndetse no kurekurwa kwa cytokine. Kugabanya igihe kirekire umusaruro wa ROS bishobora kugabanya ibara ry'uruhu n'inkovu.
Nubwo hari uburyo bwo kuvura ibiheri by'uruhu, akenshi burahenda kandi bushobora kugira ingaruka mbi nyinshi zitari ngombwa.
Ibisubizo bigaragaza ko FRO ifite ubushobozi bwo kurwanya bagiteri zitera ibiheri (CA) mu kurwanya indwara ziterwa n’ibicurane, bityo bikaba bigaragaza ko FRO ari uburyo karemano, budahumanya kandi buhendutse bwo kuvura ibiheri gakondo. FRO kandi igabanya ikorwa rya sebum no gukora imisemburo muri vitro, igaragaza akamaro kayo mu kuvura no gukumira kurwara ibiheri.
Igerageza rya FRO ryabanje ryagaragaje ko abantu bakoreshaga toner na lotion bya FRO byateye imbere bagaragaje iterambere rikomeye mu bushobozi bw'uruhu no mu bushyuhe bw'uruhu ugereranije n'itsinda ryagenzuwe nyuma y'ibyumweru bitandatu gusa. Nubwo ubu bushakashatsi butasuzumye ibiheri mu gihe byagenzuwe mu buryo bwa "in vitro", ibisubizo byabwo bishyigikira ibyo bavumbuye.
Ibyo bisubizo byose hamwe bishyigikira ikoreshwa rya FRO mu kuvura ubwiza, harimo no kuvura ibiheri no kunoza ubuzima bw'uruhu muri rusange.
Iyi nkuru yahinduwe ku ya 9 Kamena 2023 kugira ngo isimbuze ishusho nyamukuru n'iyikwiriye kurushaho.
Byashyizwe muri: Amakuru ya Siyansi y'Ubuvuzi | Amakuru y'Ubushakashatsi ku Buvuzi | Amakuru y'Indwara | Amakuru y'Imiti
Amagambo ahinnye: ibiheri, ingimbi, androgens, kurwanya ububyimbirwe, uturemangingo, chromatography, cytokines, dihydrotestosterone, imikorere, fermentation, genetics, ibintu bikura, umusatsi, imisemburo, hyperpigmentation, in vitro, inflammation, insuline, phototherapy, liquid chromatography, ogisijeni, proliferation, quercetin, retinoids, uruhu, uturemangingo tw'uruhu, ibara ry'uruhu, Western blot
Hugo Francisco de Souza ni umwanditsi w’ubumenyi ukorera i Bangalore, muri Karnataka, mu Buhinde. Ashishikajwe n’ubumenyi bwe mu bijyanye n’ibinyabuzima, ibinyabuzima by’ihindagurika ry’ikirere na herpetology. Ubu arimo gukora ku nyandiko ye ya dogitora, yakuye mu Kigo cy’Ubumenyi bw’Ibidukikije mu Kigo cy’Ubumenyi bw’Abahinde, aho yiga inkomoko, ikwirakwizwa n’imiterere y’inzoka zo mu bishanga. Hugo yahawe impamyabumenyi ya DST-INSPIRE Fellowship kubera ubushakashatsi bwe bwa dogitora n’umudari wa Zahabu muri Kaminuza ya Pondicherry kubera ibyo yagezeho mu masomo ye ya Master's. Ubushakashatsi bwe bwasohotse mu binyamakuru byasuzumwe n’urungano birimo PLOS Neglected Tropical Diseases na Systems Biology. Iyo adakora kandi atandika, Hugo yiga cyane anime na comics, yandika kandi agahimba umuziki kuri gitari ya bass, agaca indirimbo kuri MTB, agakina imikino ya videwo (akunda ijambo "umukino"), cyangwa agahindura ikoranabuhanga mu buryo bwose.
Francisco de Souza, Hugo. (Ku ya 9 Nyakanga 2023). Uruvange rudasanzwe rw'ibimera bivangwa bitanga akamaro gakomeye ko kurwanya ibiheri. Amakuru - Ubuvuzi. Byakuwe ku ya 11 Nzeri 2023, kuri https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Francisco de Souza, Hugo. “Uruvange rudasanzwe rw’ibimera bifite ubushobozi bukomeye bwo kurwanya ibiheri.” Amakuru – Ubuvuzi. 11 Nzeri 2023.
Francisco de Souza, Hugo. “Uruvange rudasanzwe rw’ibimera bifite ubushobozi bukomeye bwo kurwanya ibiheri.” Amakuru – Ubuvuzi. https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx. (Byabonetse ku ya 11 Nzeri 2023).
Francisco de Souza, Hugo. 2023. Uruvange rudasanzwe rw'ibimera bifite ubushobozi bukomeye bwo kurwanya ibiheri. News Medical, yagejejweho ku ya 11 Nzeri 2023, https://www.news-medical.net/news/20230709/Unique-plant-extract-mixture-has-pot-anti-acne-effects.aspx.
Amafoto yakoreshejwe muri iyi "ncamake" ntaho ahuriye n'ubu bushakashatsi kandi arabeshya cyane mu kugaragaza ko ubushakashatsi bwakorewe ku bantu. Agomba gukurwaho ako kanya.
Mu kiganiro cyabereye mu nama ya SLAS EU 2023 yabereye i Buruseli mu Bubiligi, twaganiriye na Silvio Di Castro ku bushakashatsi bwe n'uruhare rw'imicungire y'ibinyabutabire mu bushakashatsi ku miti.
Muri iyi podcast nshya, Keith Stumpo wo muri Bruker aganira ku mahirwe menshi y’ibicuruzwa karemano hamwe na Pelle Simpson wo muri Enveda.
Muri iki kiganiro, NewsMedical iganira n'umuyobozi mukuru wa Quantum-Si, Jeff Hawkins, ku mbogamizi ziterwa n'uburyo gakondo bwo gukora poroteyine n'uburyo gahunda yo gukurikirana poroteyine mu gihe kizaza ishobora gutuma gahunda yo gukurikirana poroteyine ihinduka.
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