Dukoresha kuki kugirango tunoze uburambe.Mugukomeza gushakisha kururu rubuga, wemera gukoresha kuki.Andi makuru.
Ukanze "Emerera Byose", wemera kubika kuki kubikoresho byawe kugirango utezimbere urubuga, gusesengura imikoreshereze yurubuga, kandi ushyigikire ibyo dutanga kubuntu, kubuntu kubuntu.Andi makuru.
Mu bushakashatsi buherutse gusohoka mu kinyamakuru Pharmaceutics, abashakashatsi bagaragaje ko imiti igabanya ubukana bwa formula y'ibimera yitwa FRO irwanya indwara ya acne.
Isuzuma rya mikorobe no mu isesengura rya vitro ryerekanye ko FRO ifite ingaruka zikomeye za antibacterial na anti-inflammatory anti Dermatobacillus Acnes (CA), bagiteri itera acne.Ibisubizo byerekana uburyo bwizewe kandi busanzwe muburyo bwo kwisiga bwa acne, bishyigikira ikoreshwa ryubundi buryo butari uburozi kandi buhendutse kumiti ya acne.
Kwiga: Ingaruka za FRO mugutera indwara ya acne vulgaris.Inguzanyo y'ishusho: Steve Jungs / Shutterstock.com
Acne vulgaris, ikunze kwitwa pimples, ni indwara isanzwe y'uruhu iterwa n'umusatsi wafunze umusatsi hamwe na selile y'uruhu rwapfuye.Acne yibasira abarenga 80 ku ijana byingimbi kandi, nubwo bidahitana abantu, bishobora gutera akababaro ko mumutwe, kandi mugihe gikomeye, uruhu rwuruhu ruhoraho hamwe ninkovu.
Acne ituruka ku mikoranire yibintu bikomoka ku bidukikije no ku bidukikije, akenshi biterwa n'imihindagurikire ya hormone ijyana n'ubugimbi mu gihe cy'ubugimbi.Iyi misemburo ya hormone yongera umusaruro wa sebum kandi ikongera insuline ikura ya 1 (IGF-1) hamwe na dihydrotestosterone (DHT).
Kwiyongera kwa sebum bifatwa nkicyiciro cya mbere mugukura kwa acne, kubera ko imisatsi yuzuye imisemburo yuzuyemo mikorobe nyinshi nka SA.SA ni ibintu bisanzwe byuruhu;icyakora, kwiyongera kwinshi kwa phylotype IA1 itera gutwika no gutondekanya imisatsi yimisatsi hamwe na papula igaragara hanze.
Hariho uburyo butandukanye bwo kwisiga kuri acne, nka retinoide hamwe na mikorobe yibanze, bikoreshwa muguhuza ibishishwa bya chimique, lazeri / kuvura urumuri, hamwe na hormone.Nyamara, ubwo buvuzi buhenze cyane kandi bufitanye isano n'ingaruka mbi.
Ubushakashatsi bwibanze bwakoze ubushakashatsi ku bimera nkibisanzwe bikoresha uburyo busanzwe bwo kuvura.Nkubundi buryo, ibice bya Rhus vulgaris (RV) byizwe.Ariko, imikoreshereze yacyo igarukira kuri urushiol, urufunguzo rwa allergique yiki giti.
FRO ni amata y'ibyatsi arimo ibimera bivanze bya RV (FRV) na mangostine yo mu Buyapani (OJ) ku kigereranyo cya 1: 1.Imikorere ya formula yageragejwe hakoreshejwe vitro assays na antimicrobial.
Imvange ya FRO yabanje kurangwa hakoreshejwe imikorere ya chromatografiya ikora cyane (HPLC) kugirango yitarure, imenye kandi igereranye ibiyigize.Uruvange rwongeye gusesengurwa kubintu byose bya fenolike (TPC) kugirango hamenyekane ibice bishobora kuba bifite imiti yica mikorobe.
Ibanze muri vitro antimicrobial assay mugusuzuma disikuru ikwirakwizwa.Ubwa mbere, CA (phylotype IA1) yari ifite umuco umwe ku isahani ya agar yashyizwemo mm 10 ya diameter ya FRO yatewe na disiki yimpapuro.Ibikorwa bya mikorobe byapimwe mugupima ubunini bwakarere kibuza.
Imikorere ya FRO ku musaruro wa sebum iterwa na CA hamwe na DHT ifitanye isano na androgène yatewe hifashishijwe amavuta atukura hamwe na Western blot isesengura.FRO yaje kugeragezwa kubushobozi bwayo bwo gutesha agaciro ingaruka zubwoko bwa ogisijeni ikora (ROS), ishinzwe kuvura hyperpigmentation ziterwa na acne hamwe n’inkovu nyuma yo kubagwa, ikoresheje iperereza rya 2 ′, 7′-dichlorofluorescein (DCF-DA).impamvu.
Ibisubizo byubushakashatsi bwakwirakwijwe bwa disiki bwerekanye ko 20 μL ya FRO yabujije gukura kwa CA kandi itanga akarere kagaragara ko kubuza mm 13 kuri 100 mg / mL.FRO ihagarika cyane ubwiyongere bwururenda rwa sebum rwatewe na SA, bityo bikadindiza cyangwa bigahindura ibibaho bya acne.
FRO byagaragaye ko ikungahaye kuri fenolike irimo aside gallic, kaempferol, quercetin na fisetin.Igiteranyo cya fenolike yuzuye (TPC) yagereranije 118.2 mg ya aside gallic ihwanye na (GAE) kuri garama FRO.
FRO yagabanije cyane gutwika selile yatewe na SA iterwa na ROS no kurekura cytokine.Kugabanuka igihe kirekire mubikorwa bya ROS birashobora kugabanya hyperpigmentation hamwe ninkovu.
Nubwo kuvura dermatologiya kuri acne bibaho, akenshi bihenze kandi birashobora kugira ingaruka nyinshi zitifuzwa.
Ibisubizo byerekana ko FRO ifite imiti igabanya ubukana bwa CA (bagiteri itera acne), bityo ikerekana ko FRO ari uburyo busanzwe, butagira uburozi kandi buhenze cyane muburyo bwo kuvura acne gakondo.FRO igabanya kandi umusaruro wa sebum no kwerekana imisemburo muri vitro, ikerekana akamaro kayo mukuvura no gukumira acne.
Igeragezwa rya kliniki ya FRO ryerekanye ko abantu bakoresha toner na lisansi ya FRO byateye imbere cyane muburyo bworoshye bwuruhu nubushyuhe ugereranije nitsinda rishinzwe kugenzura nyuma yibyumweru bitandatu gusa.Nubwo ubu bushakashatsi butasuzumye acne iyobowe na vitro, ibisubizo biriho bishyigikira ibyo babonye.
Ufatiye hamwe, ibisubizo bishyigikira ikoreshwa rya FRO mugihe cyo kwisiga, harimo kuvura acne no kuzamura ubuzima bwuruhu muri rusange.
Iyi ngingo yahinduwe ku ya 9 Kamena 2023 kugirango isimbuze ishusho nyamukuru nindi ikwiye.
Byoherejwe muri: Amakuru yubumenyi bwubuvuzi |Amakuru yubushakashatsi bwubuvuzi |Amakuru yindwara |Amakuru yimiti
Etiquetas: acne, ingimbi, androgene, anti-inflammatory, selile, chromatografiya, cytokine, dihydrotestosterone, imikorere, fermentation, genetique, ibintu bikura, umusatsi, imisemburo, hyperpigmentation, muri vitro, inflammation, insuline, Phototherapy, chromatografiya, ogisijeni, ikwirakwizwa , quercetin, retinoide, uruhu, selile zuruhu, pigmentation yuruhu, blot yo muburengerazuba
Hugo Francisco de Souza ni umwanditsi wa siyansi ufite icyicaro i Bangalore, Karnataka, mu Buhinde.Inyungu zamasomo ziri mubice bya biogeografiya, ibinyabuzima byabayeho biturutse ku bwihindurize na herpetology.Kuri ubu arimo gukora impamyabumenyi y'ikirenga.avuye mu kigo cy’ubumenyi bw’ibidukikije mu kigo cy’ubumenyi cy’Ubuhinde, aho yiga inkomoko, ikwirakwizwa n’ibisobanuro by’inzoka zo mu gishanga.Hugo yahawe igihembo cya DST-INSPIRE kubera ubushakashatsi bwe bwa dogiteri n'umudari wa zahabu wo muri kaminuza ya Pondicherry kubera ibyo yize mu masomo ya Master.Ubushakashatsi bwe bwasohotse mu binyamakuru-byasuzumwe cyane mu binyamakuru birimo PLOS Yirengagije Indwara zo mu turere dushyuha hamwe na Biologiya.Iyo adakora kandi yandika, Hugo ashingira kuri toni ya anime na comics, yandika kandi ahimba umuziki kuri gitari ya bass, acamo ibice kuri MTB, akina imikino yo kuri videwo (akunda ijambo "umukino"), cyangwa tinkers hamwe nibintu byose. .ikoranabuhanga.
Francisco de Souza, Hugo.(Ku ya 9 Nyakanga 2023).Uruvange rwihariye rwibimera rutanga inyungu zikomeye zo kurwanya acne.Amakuru - Ubuvuzi.Yakuwe ku ya 11 Nzeri 2023, avuye kuri https://www.amakuru-amakuru-yamakuru.net/amakuru/20230709/Unique-plant-inyandiko-yimikoranire-yerekana-pot-anti-acne-ingaruka.aspx.
Francisco de Souza, Hugo.Ati: "Uruvange rwihariye rw'ibimera bifite imiti irwanya acne."Amakuru - Ubuvuzi.Ku ya 11 Nzeri 2023.
Francisco de Souza, Hugo.Ati: "Uruvange rwihariye rw'ibimera bifite imiti irwanya acne."Amakuru - Ubuvuzi.https://www.amakuru-amakuru-yamakuru.net/amakuru/20230709/Ibihe bidasanzwe(Yemezwa ku ya 11 Nzeri 2023).
Francisco de Souza, Hugo.2023. Uruvange rwihariye rwibikomoka ku bimera bifite imbaraga zo kurwanya acne.Amakuru Yubuvuzi, yageze ku ya 11 Nzeri 2023,
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Mu kiganiro cyakorewe mu nama ya SLAS EU 2023 yabereye i Buruseli mu Bubiligi, twaganiriye na Silvio Di Castro ku bushakashatsi bwe ndetse n'uruhare rw'imicungire y’imiti mu bushakashatsi bwa farumasi.
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