Umubiri wawe urayikoresha mugukora serotonine, intumwa yimiti yohereza ibimenyetso hagati yingirangingo.
Serotonine nkeya yahujwe no kwiheba, guhangayika, guhagarika ibitotsi, kwiyongera ibiro, nibindi bibazo byubuzima (1, 2).
Kugabanya ibiro byongera imisemburo itera inzara. Uku kumva uhorana inzara birashobora gutuma kugabanya ibiro bidashoboka mugihe kirekire (3, 4, 5).
5-HTP irashobora kurwanya iyi misemburo itera inzara igabanya ubushake bwo kurya no kugufasha kunanuka (6).
Mu bushakashatsi bumwe, abarwayi ba diyabete 20 bahawe amahirwe yo kwakira 5-HTP cyangwa umwanya wabo mu byumweru bibiri. Ibisubizo byerekanye ko abakiriye 5-HTP banywa karori nkeya 435 kumunsi ugereranije nitsinda rya placebo (7).
Ikirenzeho, 5-HTP irwanya cyane cyane gufata karubone, ifitanye isano no kurwanya glycemic nziza (7).
Ubundi bushakashatsi bwinshi bwerekanye kandi ko 5-HTP yongera guhaga kandi igatera kugabanuka kubantu bafite umubyibuho ukabije cyangwa umubyibuho ukabije (8, 9, 10, 11).
Byongeye kandi, ubushakashatsi bw’inyamaswa bwerekanye ko 5-HTP ishobora kugabanya ibiryo bikabije kubera guhangayika cyangwa kwiheba (12, 13).
5-HTP irashobora kuba ingirakamaro mukwongera guhaga, ishobora kugufasha kurya bike no kugabanya ibiro.
Nubwo impamvu nyayo itera kwiheba itazwi cyane, abashakashatsi bamwe bemeza ko ubusumbane bwa serotonine bushobora kugira ingaruka kumyumvire yawe, bikagutera kwiheba (14, 15).
Mubyukuri, ubushakashatsi butandukanye bwerekanye ko 5-HTP ishobora kugabanya ibimenyetso byo kwiheba. Ariko, babiri muribo ntibakoresheje umwanya wo kugereranya, wagabanije agaciro k'ibisubizo byabo (16, 17, 18, 19).
Nyamara, ubushakashatsi bwinshi bwerekanye ko 5-HTP ifite imbaraga zikomeye zo kurwanya antidepressant iyo ikoreshejwe hamwe nibindi bintu cyangwa imiti igabanya ubukana kuruta iyo ikoreshwa wenyine (17, 21, 22, 23).
Byongeye kandi, isuzuma ryinshi ryanzuye ko hakenewe ubushakashatsi bwujuje ubuziranenge mbere ya 5-HTP ishobora gusabwa kuvura indwara yo kwiheba (24, 25).
5-Inyongera ya HTP yongerera urugero rwa serotonine mu mubiri, ishobora kugabanya ibimenyetso byo kwiheba, cyane cyane iyo ihujwe nindi miti igabanya ubukana cyangwa imiti. Ariko, ubushakashatsi burakenewe.
5-Kwiyongera kwa HTP birashobora kunoza ibimenyetso bya fibromyalgia, indwara irangwa n'imitsi n'amagufwa hamwe n'intege nke muri rusange.
Kugeza ubu nta mpamvu izwi itera fibromyalgia, ariko urugero rwa serotonine nkeya rwahujwe nubuzima (26Twizewe).
Ibi bituma abashakashatsi bemeza ko kuzamura urwego rwa serotonine hamwe ninyongera 5-HTP bishobora kugirira akamaro abantu barwaye fibromyalgia (27).
Mubyukuri, ibimenyetso byambere byerekana ko 5-HTP ishobora kunoza ibimenyetso bya fibromyalgia, harimo kubabara imitsi, ibibazo byo gusinzira, guhangayika, numunaniro (28, 29, 30).
Nyamara, ntabwo ubushakashatsi buhagije bwakozwe kugirango hafatwe imyanzuro ihamye kubyerekeye akamaro ka 5-HTP mugutezimbere ibimenyetso bya fibromyalgia.
5-HTP yongera urugero rwa serotonine mu mubiri, ishobora kugabanya bimwe mu bimenyetso bya fibromyalgia. Ariko, ubushakashatsi burakenewe.
5-HTP bivugwa ko ifasha kuvura migraine, ubwoko bwumutwe akenshi buherekezwa no kugira isesemi cyangwa guhungabana.
Mugihe impanvu yabyo igibwaho impaka, abashakashatsi bamwe bemeza ko biterwa na serotonine nkeya (31, 32).
Ubushakashatsi bwakozwe n'abantu 124 bwagereranije ubushobozi bwa 5-HTP na methylergometrine, imiti isanzwe ya migraine, kugirango birinde umutwe wa migraine (33).
Ubushakashatsi bwerekanye ko gufata 5-HTP buri munsi mu gihe cy’amezi atandatu byabujije cyangwa byagabanije cyane umubare w’ibitero bya migraine ku bantu 71% (33).
Mu bundi bushakashatsi bwakozwe ku banyeshuri 48, 5-HTP yagabanije inshuro 70 kubabara umutwe ugereranije na 11% mu itsinda rya placebo (34).
Mu buryo nk'ubwo, ubundi bushakashatsi bwinshi bwerekanye ko 5-HTP ishobora kuba uburyo bwiza bwo kuvura migraine (30, 35, 36).
Melatonin igira uruhare runini mugutunganya ibitotsi. Urwego rwayo rutangira kuzamuka nijoro kugirango rutere ibitotsi no kugwa mugitondo kugirango bigufashe kubyuka.
Kubwibyo, 5-HTP inyongera irashobora guteza ibitotsi mukongera umusaruro wa melatonine mumubiri.
Ubushakashatsi bwakozwe n'abantu bwerekanye ko guhuza 5-HTP na gamma-aminobutyric aside (GABA) byagabanije cyane igihe bifata cyo gusinzira, kongera igihe cyo gusinzira, no kunoza ibitotsi (37).
GABA nintumwa yimiti iteza imbere kuruhuka. Kubihuza na 5-HTP birashobora kugira ingaruka zo guhuza (37).
Mubyukuri, ubushakashatsi bwinshi bwinyamaswa nudukoko bwerekanye ko 5-HTP itezimbere ibitotsi ndetse bikaba byiza iyo ihujwe na GABA (38, 39).
Mugihe ibisubizo bitanga icyizere, kubura ubushakashatsi bwabantu biragoye gusaba 5-HTP kunoza ireme ryibitotsi, cyane cyane iyo bikoreshejwe wenyine.
Abantu bamwe barashobora kugira isesemi, impiswi, kuruka, no kubabara munda mugihe bafata 5-HTP. Izi ngaruka mbi ziterwa nigipimo, bivuze ko zigenda ziyongera uko igipimo cyiyongera (33).
Kugira ngo ugabanye izo ngaruka mbi, tangira ukoresheje urugero rwa mg 50-100 mg kabiri kumunsi kandi wongere ku kigero gikwiye mu byumweru bibiri (40).
Imiti imwe n'imwe yongera umusaruro wa serotonine. Guhuza iyi miti na 5-HTP birashobora gutera urugero rwa serotonine mu mubiri. Ibi byitwa syndrome ya serotonine, ibintu bishobora guhitana ubuzima (41).
Imiti ishobora kongera urugero rwa serotonine mu mubiri harimo imiti igabanya ubukana, imiti ikorora, cyangwa imiti igabanya ububabare.
Kuberako 5-HTP ishobora kandi guteza imbere ibitotsi, kuyifata hamwe na imiti igabanya ubukana nka Klonopin, Ativan, cyangwa Ambien bishobora gutera ibitotsi byinshi.
Kubera imikoranire mibi ishoboka nindi miti, banza ubaze muganga wawe cyangwa farumasi mbere yo gufata inyongera 5-HTP.
Mugihe ugura ibyongeweho, shakisha kashe ya NSF cyangwa USP yerekana ubuziranenge. Izi nisosiyete zagatatu zemeza ko inyongera zirimo ibivugwa kuri label kandi bitarimo umwanda.
Abantu bamwe bashobora guhura n'ingaruka mugihe bafata 5-HTP. Menyesha muganga wawe mbere yo gufata 5-HTP kugirango umenye neza ko ari umutekano wawe.
Izi nyongera ziratandukanye ninyongera ya L-tryptophan, ishobora kandi kongera serotonine (42).
L-tryptophan ni aside amine yingenzi iboneka mu biribwa bikungahaye kuri poroteyine nk'amata, inkoko, inyama, soya, na soya.
Ku rundi ruhande, 5-HTP ntabwo iboneka mu biryo kandi irashobora kongerwa gusa mu mirire yawe binyuze mu byongera ibiryo (43).
Umubiri wawe uhindura 5-HTP muri serotonine, ibintu bigenga ubushake bwo kurya, kumva ububabare, no gusinzira.
Urwego rwo hejuru rwa serotonine rushobora kugira inyungu nyinshi, nko kugabanya ibiro, kugabanya ibimenyetso byo kwiheba na fibromyalgia, kugabanya inshuro nyinshi ibitero bya migraine, no gusinzira neza.
Ingaruka ntoya zahujwe na 5-HTP, ariko izi zirashobora kugabanywa utangiriye kuri dosiye nto hanyuma ukongera buhoro buhoro.
Urebye ko 5-HTP ishobora gukorana nabi n'imiti imwe n'imwe, baza muganga wawe kugirango urebe ko ari umutekano kuri wewe.
Inzobere zacu zihora zikurikirana ubuzima nubuzima bwiza no kuvugurura ingingo zacu uko amakuru mashya aboneka.
5-HTP isanzwe ikoreshwa nkinyongera kugirango serotonine igabanuke. Ubwonko bukoresha serotonine kugirango igabanye umwuka, ubushake, nibindi bikorwa byingenzi. ariko…
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