RutinFormula y'imiti ni (C27H30O16 •3H2O), vitamine, ifite akamaro ko kugabanya kwinjira no kwangirika kw'imitsi yo mu bwonko, ikomeza kandi igasubiza ubushobozi bwo guhagarara neza kw'imitsi yo mu bwonko. Mu rwego rwo gukumira no kuvura kuva amaraso menshi mu bwonko, kuva amaraso mu maso kw'ijisho ry'umurwayi wa diyabete na purpura yo kuva amaraso nabyo bikoreshwa nk'ibintu birwanya ubukana bw'ibiryo n'amabara.

Igabanyijemo ibipimo bine bikurikira:

1. Rutin NF11: ifu y'umuhondo-icyatsi kibisi, cyangwa kristu ntoya cyane; Nta mpumuro, nta buryohe; Ibara ryijimye mu kirere; Ishyushye kugeza kuri 185-192 ℃, iba umubiri w'umukara wa gelatin hanyuma ibora kuri 215 ℃. Ishonga gato muri ethanol ishyushye, ishonga gato mu mazi abira, ishonga gato mu mazi akonje, yoroshye gushonga muri isopropyl alcohol na methanol, ntishonga muri trichloromethane, ether na benzene; Ishonga mu gisubizo cya alkali hydroxide. Uburyo bwo kuyimenya ni A: aside hydrochloric reflux hydrolysis kuri quercetin, aho ishonga ari 312 ℃ B: imvura itukura ya oxide cuprous. C: Kongeramo umuti wa sodium hydroxide ni umuhondo w'icunga D: umuti wa ethanol na ferric chloride ni umukara w'icyatsi kibisi E: umuti wa ethanol ufite aside hydrochloric na magnesium buhoro buhoro: ≥95.0% (UV) (n'ibicuruzwa byumye)

Kugabanya ibiro byumye: 5.5% ~ 9.0%

Ibisigazwa bitwikwa ≤0.5%

Chlorophyll ≤0.004%

Ibara ry'umutuku ≤0.004%

Ibikomoka kuri quercetin bifitanye isano ≤5.0% (UV)

Umubare wose wa bagiteri zo mu bwoko bwa aerobic ≤103cfu/g

Umubare wose w'ibihumyo n'umusemburo ≤102cfu/g

Escherichia coli ntigomba kugaragara /g

Uburyo bwo kubika Bika mu gikoresho gifunguye neza kure y'urumuri.

2. Rutoside Trihydrate EP 9.0: Ifu y'umuhondo cyangwa iy'icyatsi kibisi. Irashongesha mu mazi hafi ya yose, irashongesha mu methanol, irashongesha gato muri ethanoli (96%), irashongesha mu mazi hafi ya yose. Irashongesha mu gisubizo cya hydroxide. Uburyo bwo kuyimenya ni ubu bukurikira :A: Ifu ishobora kwinjiza amazi menshi kuri 257nm na 358nm, kandi igipimo cyo kwinjiza amazi kinini kuri 358nm ni 305 ~ 330. B: Imiterere y'ifatizo ry'ifatizo rigomba kuba rijyanye n'iry'igisubizo C: Utudomo tw'ibara rimwe n'ingano imwe tuzagaragara aho chromatogramu y'igisubizo D: umuti wa ethanoli ufite aside hydrochloric na zinc uzagaragaza umutuku

Ibikubiye muri 95.0% ~ 101.0% (ku gicuruzwa cyumye) (umubare w'ibipimo)

Ubushuhe 7.5% ~ 9.5% (Cartesian)

Ibisigazwa bitwikwa ≤0.1%

Agaciro ntarengwa k'imyanda y'urumuri ifata urumuri ruri hagati ya 450nm na 800nm ​​ntikagomba kurenza 0.10

Ibintu bidashonga muri methanol ≤3.0%

Ibiyobyabwenge bifitanye isano na isoquercetin ≤2.0%, kaempferol-3-rutin ≤2.0%, quercetin ≤2.0%, umwanda wose ≤4.0% (HPLC)

Umubare wose wa bagiteri zo mu bwoko bwa aerobic ≤104cfu/g

Umubare wose w'ibihumyo n'umusemburo ≤102cfu/g

Bagiteri zidafite gram-bile ≤102cfu/g

Escherichia coli ntigomba kugaragara /g

Salmonella ishobora kutagaragara / 25g

Uburyo bwo kubika ibintu burinda urumuri

3. Rutin USP43: Uburyo bwo kumenya ni A: ubushobozi ntarengwa bwo kwinjiza kuri 257nm na 358nm, naho ubushobozi ntarengwa bwo kwinjiza kuri 358nm ni 305 ~ 33. B: Uburyo bwo kwinjiza bwa infrared bugomba kuba buhuye na chromatogram y'umusaruro w'icyitegererezo. C: Igihe cyo kubika uburebure bwa chromatogram kigomba kuba gihuye n'igihe cy'umusaruro w'icyitegererezo.

Ibikubiye muri 95.0% ~ 101.0% (ku gicuruzwa cyumye) (umubare w'ibipimo)

Ubushuhe 7.5% ~ 9.5% (Cartesian)

Ibisigazwa bitwikwa ≤0.1%

Agaciro ntarengwa k'imyanda y'urumuri ifata urumuri ruri hagati ya 450nm na 800nm ​​ntikagomba kurenza 0.10

Ibintu bidashonga muri methanol ≤3.0%

Ibikoresho bifitanye isano na isoquercetin ≤2.0%, kaempferol-3-rutin ≤2.0%, quercetin ≤2.0%, ibindi bintu bitandukanye ≤1.0%, umwanda wose ≤4.0% (HPLC)

Umubare wose wa bagiteri zo mu bwoko bwa aerobic ≤104cfu/g

Umubare wose w'ibihumyo n'umusemburo ≤103cfu/g

Escherichia coli ntigomba kugaragara / 10g

Salmonella ntigomba kugaragara / 10g

Uburyo bwo kubika bufunze kandi burinzwe kure y'urumuri.

4. Ibipimo ngenderwaho bya Minisiteri WS1-49(B)-89 bya Rutinum: ifu y'umuhondo cyangwa umuhondo-icyatsi kibisi, cyangwa kristu ntoya cyane; Nta mpumuro, nta buryohe; Ibara ryijimye mu kirere; Rishyushye kugeza kuri 185 ~ 192℃ kugira ngo rihinduke gel y'umukara. Rishongesha gato muri ethanol ibira, rishongesha gato mu mazi abira, rishongesha gato mu mazi akonje, ntirishongesha muri trichloromethane na ether; Rishongesha mu gisubizo cya alkali hydroxide. Uburyo bwo kubimenya ni: A: umutuku utukura wa oxide. B: Imiterere y'ingufu za infrared igomba kuba ijyanye n'iy'ikintu gigenzura. C: Inyongesha ntarengwa iboneka ku bunini bwa 259±1nm na 362.5±1nm.

Ibikubiye muri ≥93.0% (UV) (ku gicuruzwa cyumye)

Kugabanya ibiro byumye 5.5% ~ 9.0%

Ibisigazwa bitwikwa ≤0.3%

Ibintu bidashonga muri methanol ≤2.5% (ibintu bidashonga muri ethanol)

Ibikomoka kuri quercetin bifitanye isano ≤4.0% (Urutonde rworoheje)

Umubare wose wa bagiteri zo mu bwoko bwa aerobic ≤103cfu/g

Umubare wose w'ibihumyo n'umusemburo ≤102cfu/g

Escherichia coli ntigomba kugaragara /g

Salmonella ntigomba kugaragara /g

Uburyo bwo kubika bufunze kandi burinzwe kure y'urumuri.

Ingaruka z'imiti:

Igikorwa cyo kurwanya ihindagurika ry’imitsi

Molekile za ogisijeni zigabanuka mu buryo bwa electron imwe mu mikorere y'uturemangingo, kandi iyoni za O zikomoka ku kugabanuka kwa molekile za ogisijeni mu buryo bwa electron imwe zizatanga H2O2 na radicals za OH zirimo uburozi bwinshi mu mubiri, bityo bigira ingaruka ku buryo uruhu rugenda neza ndetse binatuma uruhu rusaza vuba. Byongeye kandi, kongeramo rutin mu gicuruzwa bishobora gukuraho ubwoko bwa ogisijeni bukorwa n'uturemangingo. Rutin ni igikoresho cya flavonoid, kikaba ari antioxydant ikomeye yo gukuraho radicals zirimo free. Ishobora guhagarika uruhererekane rw'imisemburo ya free radicals, ikabuza peroxidation ya aside polyunsaturated fatty acids kuri biofilms, ikavanaho lipid peroxidation products, ikarinda ubusugire bwa biofilms n'imiterere y'uturemangingo, kandi ikagira uruhare runini mu mubiri. [2]

Kurwanya peroxidation y'amavuta

Kugabanya ibinure mu maraso bivuga urukurikirane rw'ibikorwa byo kugabanya ibinure biterwa n'ubwoko bwa ogisijeni bwibasira aside y'ibinure ya polyunsaturated muri biofilms. Zhu Jianlin n'abandi. Bagennye kandi basesenguye imikorere ya SOD mu mbeba, ingano y'umusaruro wa MDA, hamwe n'ingano ya Lipofuscin mu mwijima munini, maze basanga rutin yagize ingaruka ku kugabanya ibinure mu mbeba zaciwe, kandi ishobora kubuza ubushobozi bwa antioxydant mu mbeba nyuma yo gucibwa. Rutin ishobora kurwanya kugabanuka k'ubushobozi bwa antioxydant buterwa no kugabanuka kwa estrogene y'umwimerere kandi ifite ingaruka za antioxydant. Lipoprotein ifite ubucucike bwinshi (HDL) igira ingaruka zo kurwanya atherosclerotic. Ariko, HDL, kimwe na lipoprotein ifite ubucucike buke (LDL) na lipoprotein ifite ubucucike buke cyane (VLDL), ishobora kandi guhindurwa no guhinduka muri vitro. Iyo HDL imaze guhindurwa no guhinduka Ox-HDL, igira ingaruka za atherosclerosis. Meng Fang n'abandi bakoze ubushakashatsi ku ngaruka za rutin ku guhindura HDL oxidative hakoreshejwe Cu2+ oxidative modification muri vitro. Umwanzuro Rutin ishobora kubuza cyane guhindura HDL oxidative. [2]

Ingaruka mbi z'ikintu gituma platelet ikora

Iterambere ry’indwara nyinshi z’umutima n’imitsi yo mu bwonko, nka thrombosis, atherosclerosis, inflammatory reaction na ischemia-reperfusion free radical injury, bifitanye isano rya hafi no guhuza plateletactivating factor (PAF). Kubwibyo, kurwanya ingaruka za PAF ni uburyo bw'ingenzi bwo kugabanya indwara z’umutima n’imitsi yo mu bwonko. Ubushakashatsi bwagaragaje ko rutin ishobora kurwanya uburyo PAF ifatana na platelet membrane receptors bitewe n’ubwinshi bwayo, ikabuza platelet gufatana na PAf mu nkwavu no kongera ubwinshi bwa Ca2+ muri PMNs, bigaragaza ko uburyo rutin ikora bwo kurwanya PAF ari ukubuza PAF receptor gukora, hanyuma ikabuza PAF gukora, kugira ngo igire uruhare mu kurinda umutima. Ibisubizo byagaragaje ko rutin yari antagonist ya PAF receptor. [2]

Irwanya pancreatitis ikabije

Rutin ishobora gukumira kubura kwa kalisiyumu mu mubiri no kugabanya ubucucike bwa Ca2+ mu turemangingo twa pancreas. Byagaragaye ko rutin ishobora kongera ingano ya phospholipase A2 (PLA2) mu turemangingo twa pancreas tw’imbeba, bigaragaza ko rutin ishobora kubuza irekurwa n’ikorwa rya PLA2 mu turemangingo twa pancreas. Rutin ishobora gukumira kubura kwa kalisiyumu mu mbeba za AP, wenda binyuze mu gukumira kwinjira kwa Ca2+ no kugabanya umubyimba wa Ca2+ mu turemangingo twa pancreas, bityo bikagabanya kwangirika kwa AP. [2]

Ireferensi: https://mp.weixin.qq.com

https://xueshu.baidu.com/usercenter/paper

Ku bijyanye na rutin, twandikire. Turagutegereje hano igihe icyo ari cyo cyose.