Rutinimiti ya chimique ni (C27H30O16 • 3H2O), vitamine, ifite ingaruka zo kugabanya capillary permeability na brittleness, kubungabunga no kugarura elastique isanzwe ya capillaries. Kurinda no kuvura hypertension cerebral haemorrhage; Indwara ya diabete ya retinal na hemorhagic purpura nayo ikoreshwa nka antioxydants y'ibiryo hamwe na pigment.

Igabanijwemo ibintu bine bikurikira:

1. Rutin NF11: ifu yumuhondo-icyatsi, cyangwa kirisiti nziza cyane; Impumuro nziza, uburyohe; Ibara ryijimye mu kirere; Gushyuha kugeza 185-192 ℃, ihinduka umubiri wijimye wijimye kandi ubora nka 215 ℃. Gushonga gahoro muri Ethanol itetse, gushonga gato mumazi abira, gushonga gake cyane mumazi akonje, gushonga byoroshye muri alcool ya isopropyl na methanol, bidashonga muri trichloromethane, ether na benzene; Gukemura muri alkali hydroxide igisubizo. Uburyo bwo kumenyekanisha ni A: hydrochloric acide hydrolysis hydrolysis kuri quercetin, aho gushonga ni 312 ℃ B: imvura itukura ya cuprous itukura. C.

Kugabanya ibiro byumye: 5.5% ~ 9.0%

Gutwika ibisigazwa ≤0.5%

Chlorophyll ≤0.004%

Ibara ritukura ≤0.004%

Ibintu bifitanye isano quercetin ≤5.0% (UV)

Umubare wa bagiteri zose zo mu kirere ≤103cfu / g

Umubare wuzuye wububiko numusemburo ≤102cfu / g

Escherichia coli ntishobora kumenyekana / g

Imiterere yo kubika Ubike mu kintu cyumuyaga kitari mu mucyo.

2. Rutoside Trihydrate EP 9.0: Ifu yumuhondo cyangwa umuhondo-icyatsi. Hafi yo kudashonga mumazi, gushonga muri methanol, gushonga gake muri Ethanol (96%), hafi yo kudashonga muri chloride ya methylene. Gukemura muri hydroxide. Uburyo bwo kumenyekanisha nuburyo bukurikira: A: Kwinjiza ntarengwa kuri 257nm na 358nm, hamwe na coeffisente yo kwinjiza cyane kuri 358nm ni 305 ~ 330. B: Uburyo bwo kwinjiza infragre bugomba kuba buhuye nibicuruzwa C: Ibibanza bifite ibara rimwe kandi ingano izagaragara kumwanya uhuye na chromatogramu yibicuruzwa byerekanwe D: igisubizo cya Ethanol hamwe na aside hydrochloric na zinc bizerekana umutuku

Ibirimo 95.0% ~ 101.0% (kubicuruzwa byumye) (titre)

Ubushuhe 7.5% ~ 9.5% (Cartesian)

Gutwika ibisigazwa ≤0.1%

Agaciro ntarengwa ko kwinjiza urumuri rwa optique kuri 450nm kugeza 800nm ​​ntigomba kurenza 0.10

Ikintu kidashonga muri methanol ≤3.0%

Ibintu bifitanye isano isoquercetin ≤2.0%, kaempferol-3-rutin ≤2.0%, quercetin ≤2.0%, umwanda wose ≤4.0% (HPLC)

Umubare wa bagiteri zose zo mu kirere ≤104cfu / g

Umubare wuzuye wububiko numusemburo ≤102cfu / g

Bile gram-mbi ya bagiteri ≤102cfu / g

Escherichia coli ntishobora kumenyekana / g

Salmonella ntishobora kuboneka / 25g

Imiterere yo kubika irinda urumuri

3. Rutin USP43. C: Igihe cyo kugumana impinga ya chromatogramu igomba kuba ijyanye nigihe cyibicuruzwa

Ibirimo 95.0% ~ 101.0% (kubicuruzwa byumye) (titre)

Ubushuhe 7.5% ~ 9.5% (Cartesian)

Gutwika ibisigazwa ≤0.1%

Agaciro ntarengwa ko kwinjiza urumuri rwa optique kuri 450nm kugeza 800nm ​​ntigomba kurenza 0.10

Ikintu kidashonga muri methanol ≤3.0%

Ibintu bifitanye isano isoquercetin ≤2.0%, kaempferol-3-rutin ≤2.0%, quercetin ≤2.0%, izindi mono-zitandukanye ≤1.0%, umwanda wose ≤4.0% (HPLC)

Umubare wa bagiteri zose zo mu kirere ≤104cfu / g

Umubare wuzuye wububiko numusemburo ≤103cfu / g

Escherichia coli ntishobora kumenyekana / 10g

Salmonella ntishobora kumenyekana / 10g

Imiterere yo kubika ifunze kandi ikaguma kure yumucyo.

4. Minisiteri isanzwe WS1-49 (B) -89 ya Rutinum: ifu yumuhondo cyangwa umuhondo-icyatsi kibisi, cyangwa kristu nziza cyane; Impumuro nziza, uburyohe; Ibara ryijimye mu kirere; Gushyuha kugeza 185 ~ 192 ℃ kugirango ube gel wijimye. Gushonga buhoro muri Ethanol itetse, gushonga gato mumazi abira, gushonga gato mumazi akonje, kutaboneka muri trichloromethane na ether; Gukemura muri alkali hydroxide igisubizo. Uburyo bwo kumenya ni: A: imvura itukura ya cuprous itukura. B: Uburyo bwo kwinjiza infragre bigomba kuba bihuye nubugenzuzi. C: Kwinjira kwinshi kuboneka kuburebure bwa 259 ± 1nm na 362.5 ± 1nm.

Ibirimo ≥93.0% (UV) (kubicuruzwa byumye)

Kugabanya ibiro byumye 5.5% ~ 9.0%

Gutwika ibisigazwa ≤0.3%

Ikintu kidashonga muri methanol ≤2.5% (ibintu bitangirika muri Ethanol)

Ibintu bifitanye isano quercetin ≤4.0% (Thin layer)

Umubare wa bagiteri zose zo mu kirere ≤103cfu / g

Umubare wuzuye wububiko numusemburo ≤102cfu / g

Escherichia coli ntishobora kumenyekana / g

Salmonella ntishobora kumenyekana / g

Imiterere yo kubika ifunze kandi ikaguma kure yumucyo.

Ingaruka ya farumasi ：

Kurwanya ibikorwa bikaze

Molekile ya Oxygene igabanuka muburyo bwa electron imwe muri metabolism selile, kandi O ion zatewe no kugabanuka kwa molekile ya ogisijeni muburyo bwa electron imwe izahita itanga H2O2 nuburozi bukabije · OH radicals yubusa mumubiri, bityo bikagira ingaruka kumubiri wuruhu. ubworoherane ndetse byihutisha gusaza k'uruhu. Byongeye kandi, kongeramo rutin kubicuruzwa birashobora gukuraho ubwoko bwa ogisijeni ikora ikorwa na selile. Rutin ni ifumbire ya flavonoide, ikaba ari antioxydants ikomeye yo gushakisha radicals yubusa. Irashobora guhagarika urunigi rwimikorere ya radicals yubuntu, ikabuza peroxidisation ya acide polyunsaturated fatty acide kuri biofilm, ikuraho ibicuruzwa bya lipide peroxidation, ikarinda ubusugire bwibinyabuzima na selile, kandi bigira uruhare runini mumubiri. [2]

Kurwanya lipide peroxidation

Lipid peroxidation bivuga urukurikirane rw'ibikorwa bya okiside iterwa n'ubwoko bwa ogisijeni ikora yibasira aside irike ya polyunzure muri biofilm. Zhu Jianlin n'abandi. kugena no gusesengura ibikorwa bya SOD mu mbeba, ibikubiye mu bicuruzwa bya lipide peroxidation ya lipide yubusa-MDA, hamwe na Lipofuscine mu mwijima munini, ugasanga rutin yagize ingaruka mbi kuri lipide peroxidisation yimbeba zatewe, kandi zishobora kubuza kugabanuka kwubushobozi bwa antioxydeant. ya antioxydeant muri imbeba nyuma yo guterwa. Rutin irashobora kurwanya igabanuka ryubushobozi bwa antioxydeant iterwa no kugabanuka kwa estrogene ya endogene kandi ifite antioxydeant. Lipoproteine ​​yuzuye (HDL) ifite ingaruka zo kurwanya aterosklerotike. Nyamara, HDL, nka lipoprotein nkeya (LDL) hamwe na lipoprotein nkeya cyane (VLDL), irashobora kandi kuba oxyde kandi igahinduka muri vitro. HDL imaze guhinduka okiside igahinduka Ox-HDL, igira ingaruka za aterosklerose. Meng Fang n'abandi. yakoze iperereza ku ngaruka za rutin kuri modifike ya HDL ya Cu2 + yahinduwe na oxyde oxyde muri vitro. Umwanzuro Rutin irashobora kubuza cyane guhindura okiside ya HDL. [2]

Ingaruka ya antagonistique yibintu bikora

Indwara ziterwa n'indwara nyinshi z'umutima n'imitsi n'ubwonko, nka trombose, aterosklerose, reaction inflammatory hamwe na ischemia-reperfusion ibikomere bikabije, bifitanye isano rya hafi no guhuza ibibyimba (PAF). Kubwibyo, kurwanya ingaruka za PAF ninzira yingenzi yo kugabanya indwara zifata umutima-mitsi nindwara zifata ubwonko. Ubushakashatsi bwerekanye ko rutin ishobora kurwanya uburyo bwihariye bwo guhuza PAF n’urukwavu rwa platine membrane reseptors yakira biterwa no kwibanda ku bitekerezo, bikabuza kwishyira hamwe kwa PAf byifashishijwe mu nkwavu no kwiyongera kwa Ca2 + ku buntu muri PMNs, byerekana ko uburyo bw’ibikorwa bya rutin bwo kurwanya PAF ari kubuza gukora kwakirwa kwa PAF, hanyuma ugahagarika reaction yatewe na PAF, kugirango ugire uruhare mukurinda umutima. Ibisubizo byerekanaga ko rutin yari antagonist ya PAF. [2]

Kurwanya pancreatite

Rutin irashobora gukumira neza hypocalcemia kandi igabanya ubukana bwa Ca2 + mumyanya myibarukiro. Byagaragaye ko rutin ishobora kongera ibirimo fosifolipase A2 (PLA2) mu ngingo zitwa pancreatic tissue yimbeba, byerekana ko rutin ishobora kubuza irekurwa nogukora kwa PLA2 mumyanya myibarukiro. Rutin irashobora gukumira neza indwara ya hypocalcemia mu mbeba za AP, bishoboka ko irinda Ca2 + kwinjira no kugabanya Ca2 + kurenza urugero mu ngirabuzimafatizo za pancreatic tissue, bityo bikagabanya kwangirika kwa patrophysiologique kuri AP. [2]

Reba ： https: //mp.weixin.qq.com

https://xueshu.baidu.com/usercenter/impapuro

Kuri rutin, nyamuneka twandikire. Turagutegereje hano umwanya uwariwo wose.