Berberine, cyangwa berberine hydrochloride, ni ikinyabutabire kiboneka mu bimera byinshi. Ishobora gufasha kuvura indwara nka diyabete, cholesterol nyinshi n'umuvuduko ukabije w'amaraso. Ariko, ingaruka mbi zishobora kuba zirimo kubabara mu gifu no kugira isesemi.
Berberine imaze imyaka ibihumbi iri mu buvuzi gakondo bw'Abashinwa na Ayurvedic. Ikora mu mubiri mu buryo butandukanye kandi ishobora guteza impinduka mu turemangingo tw'umubiri.
Ubushakashatsi kuri berberine bwerekana ko ishobora kuvura indwara zitandukanye ziterwa n’imikorere y’umubiri, harimo diyabete, umubyibuho ukabije, n’indwara z’umutima. Bishobora kandi no kunoza ubuzima bw’amara.
Nubwo berberine isa nkaho ari nziza kandi ikagira ingaruka nke, ugomba kugisha inama muganga wawe mbere yo kuyifata.
Berberine ishobora kuba umuti urwanya udukoko. Ubushakashatsi bwakozwe mu 2022 bwagaragaje ko Berberine ifasha mu kugabanya ikwirakwira rya Staphylococcus aureus.
Ubundi bushakashatsi bwagaragaje ko berberine ishobora kwangiza ADN na poroteyine za bagiteri zimwe na zimwe.
Ubushakashatsi bwerekana ko berberine ifite ubushobozi bwo kurwanya ububyimbirwe, bivuze ko ishobora gufasha kuvura diyabete n'izindi ndwara zijyanye no kubyimbirwa.
Ubushakashatsi bwerekana ko berberine ishobora kuba ingirakamaro mu kuvura diyabete. Ubushakashatsi bwagaragaje ko ishobora kugira ingaruka nziza kuri:
Isesengura rimwe ryagaragaje ko kuvanga berberine n'umuti ugabanya isukari mu maraso byari ingirakamaro kurusha kimwe muri ibyo biyobyabwenge byombi.
Dukurikije ubushakashatsi bwakozwe mu 2014, berberine igaragaza icyizere nk'umuti ushobora kuvura diyabete, cyane cyane ku bantu badashobora gufata imiti igabanya diyabete isanzweho kubera indwara z'umutima, umwijima, cyangwa ibibazo by'impyiko.
Indi nyandiko yavumbuye ko berberine hamwe n'impinduka mu mibereho bigabanya urugero rw'isukari mu maraso kurusha impinduka mu mibereho gusa.
Berberine isa nkaho ikora protein kinase ikora muri AMP, ifasha mu kugenzura ikoreshwa ry'isukari mu maraso mu mubiri. Abashakashatsi bemeza ko iyi kora ishobora gufasha kuvura diyabete n'ibindi bibazo by'ubuzima bifitanye isano nko kubyibuha cyane na cholesterol nyinshi.
Ubundi bushakashatsi bwa 2020 bwagaragaje iterambere mu buremere bw'umubiri n'ibipimo bya metabolisme nta kwiyongera gukomeye mu mikorere ya enzymes z'umwijima.
Ariko, abahanga mu bya siyansi bagomba gukora ubushakashatsi bunini, budafite aho buhuriye n'amaso yabo kugira ngo bamenye neza umutekano n'ubushobozi bwa berberine.
Vugana na muganga wawe mbere yo gufata berberine ku ndwara ya diyabete. Ishobora kuba idakwiriye buri wese kandi ishobora kugira ingaruka ku yindi miti.
Urugero rwinshi rwa cholesterol na triglycerides nkeya (LDL) bishobora kongera ibyago byo kurwara indwara z'umutima na stroke.
Hari ibimenyetso bigaragaza ko berberine ishobora gufasha kugabanya cholesterol ya LDL na triglycerides. Nk’uko byagaragajwe n’isuzuma rimwe, ubushakashatsi ku nyamaswa n’abantu bwerekana ko berberine igabanya cholesterol.
Ibi bishobora gufasha kugabanya LDL, cholesterol "mbi", no kongera HDL, cholesterol "nziza".
Isuzuma ry’inyandiko ryagaragaje ko berberine hamwe n’impinduka mu mibereho y’abantu ari ingirakamaro cyane mu kuvura cholesterol nyinshi kurusha guhindura imibereho gusa.
Abashakashatsi bemeza ko berberine ishobora gukora kimwe n'imiti igabanya cholesterol idatera ingaruka zimwe.
Isuzuma ry’inyandiko ryagaragaje ko berberine igira akamaro cyane iyo ivanze n’imiti igabanya umuvuduko w’amaraso kuruta iyo ubwayo.
Byongeye kandi, ibyavuye mu bushakashatsi bw’imbeba bigaragaza ko berberine ishobora gutinza gutangira k’umuvuduko ukabije w’amaraso no gufasha kugabanya ubukana bwawo iyo umuvuduko ukabije w’amaraso ubayeho.
Isuzuma rimwe ryagaragaje ko abantu bafata miligarama 750 (mg) za barberry kabiri ku munsi mu gihe cy'amezi 3 bagabanya ibiro cyane. Barberry ni ikimera kirimo berberine nyinshi.
Byongeye kandi, ubushakashatsi bwakozwe n’abantu babiri batabona neza bwagaragaje ko abantu bafite indwara ya metabolisme bafata 200 mg ya barberry gatatu ku munsi bafite igipimo cy’uburemere bw’umubiri kiri hasi.
Itsinda ryakoze ubundi bushakashatsi ryagaragaje ko berberine ishobora gukora ku mubiri w’amavuta y’umukara. Iyi ngingo ifasha umubiri guhindura ibiryo ubushyuhe bw’umubiri, kandi kwiyongera k’imikorere y’umubiri bishobora gufasha kuvura umubyibuho ukabije n’indwara ya metabolike.
Ubushakashatsi bumwe bwerekana ko berberine ikora kimwe n'umuti wa metformin, abaganga bakunze gutanga mu kuvura diyabete yo mu bwoko bwa 2. Mu by'ukuri, berberine ishobora kuba ifite ubushobozi bwo guhindura bagiteri zo mu mara, bishobora gufasha kuvura umubyibuho ukabije na diyabete.
Indwara ya Polycystic ovary syndrome (PCOS) ibaho iyo abagore bafite urugero rwinshi rw'imisemburo imwe n'imwe y'abagabo. Iyi ndwara ni imisemburo idahuye neza n'imikorere y'umubiri ishobora gutera ubugumba n'izindi ngorane z'ubuzima.
Indwara ya polycystic ovary syndrome ifitanye isano n'ibibazo byinshi Berberine ishobora gukemura. Urugero, abantu barwaye PCOS bashobora kandi kugira:
Hari igihe abaganga batanga metformin, umuti wa diyabete, kugira ngo ivure PCOS. Kubera ko berberine igira ingaruka nk'iza metformin, ishobora no kuba uburyo bwiza bwo kuvura PCOS.
Isuzuma ryakozwe ku buryo bufatika ryagaragaje ko berberine ari nziza mu kuvura indwara y’intanga ngabo ifite ubudahangarwa bwa insuline. Icyakora, abanditsi bavuga ko kwemeza izi ngaruka bisaba ubushakashatsi bwimbitse.
Berberine ishobora guteza impinduka mu turemangingo tw’uturemangingo, bishobora kugira ikindi cyiza gishobora kuba: kurwanya kanseri.
Ubundi bushakashatsi bwerekana ko berberine ifasha kuvura kanseri igabanya iterambere ryayo n'ubuzima bwayo busanzwe. Ishobora kandi kugira uruhare mu kwica uturemangingo twa kanseri.
Bashingiye kuri aya makuru, abanditsi bavuga ko berberine ari umuti "ufite akamaro kanini, wizewe kandi uhendutse" urwanya kanseri.
Ariko, ni ngombwa kwibuka ko abashakashatsi biga gusa ingaruka za berberine ku turemangingo twa kanseri muri laboratwari ntabwo bize ku bantu.
Nk’uko ubushakashatsi bumwe na bumwe bwasohotse mu 2020 bubivuga, niba berberine ishobora gufasha kuvura kanseri, ububyimbirwe, diyabete n’izindi ndwara, bishobora kuba biterwa n’ingaruka nziza igira ku mikorobe zo mu mara. Abahanga mu bya siyansi bavumbuye isano iri hagati ya mikorobe zo mu mara (amatsinda ya bagiteri mu mara) n’izi ndwara.
Berberine ifite ubushobozi bwo kurwanya bagiteri kandi ikavanaho bagiteri mbi mu mara, bityo igatuma bagiteri nzima zikura.
Nubwo ubushakashatsi ku bantu no ku mbeba bugaragaza ko ibi bishobora kuba ari ukuri, abahanga mu bya siyansi bagaragaza ko hakenewe ubushakashatsi bwinshi kugira ngo hemezwe uburyo berberine igira ingaruka ku bantu kandi niba ari nziza kuyikoresha.
Ishyirahamwe ry’Abanyamerika ry’Abaganga b’Ibinyabuzima (AANP) rivuga ko inyongeramusaruro za berberine ziboneka mu buryo bw’inyongeramusaruro cyangwa mu buryo bwa capsule.
Bongeraho ko ubushakashatsi bwinshi busaba gufata 900-1500 mg ku munsi, ariko abantu benshi bafata 500 mg gatatu ku munsi. Nyamara, AANP isaba abantu kujya kwa muganga mbere yo gufata berberine kugira ngo barebe niba ari nziza kuyikoresha ndetse n'ingano yayo.
Niba umuganga yemeye ko berberine ari nziza kuyikoresha, abantu bagomba no kugenzura icyapa cy’umuti kugira ngo barebe ko ari uwa gatatu, nka National Science Foundation (NSF) cyangwa NSF International, nk’uko bivugwa na AANP.
Abanditsi b'ubushakashatsi bwakozwe mu 2018 basanze ibikubiye mu tuvuta twa berberine bitandukanye cyane, bishobora gutera urujijo ku mutekano n'ingano yabyo. Ntibasanze ibiciro biri hejuru bigaragaza ko ibicuruzwa bifite ubwiza buri hejuru.
Ikigo gishinzwe ibiribwa n'imiti muri Amerika (FDA) ntikigenzura inyunganiramirire. Nta gihamya cy'uko inyongeramusaruro ari nziza cyangwa zifite akamaro, kandi si ngombwa buri gihe kugenzura ubwiza bw'umuti.
Abahanga mu bya siyansi bavuga ko berberine na metformin bisangiye imiterere myinshi kandi byombi bishobora kuba ingirakamaro mu kuvura diyabete yo mu bwoko bwa 2.
Ariko, niba muganga ahaye umuntu metformin, ntagomba gutekereza kuri berberine nk'ubundi buryo atabanje kubiganiraho na muganga we.
Abaganga bazatanga metformin ikwiye ku muntu hashingiwe ku bushakashatsi bwakorewe kwa muganga. Ntibishoboka kumenya uburyo inyongeramusaruro zihuye n'iki gipimo.
Berberine ishobora kugira ingaruka kuri metformin no kugira ingaruka ku isukari yo mu maraso yawe, bigatuma bigorana kuyigenzura. Mu bushakashatsi bumwe, gufata berberine na metformin hamwe byagabanyije ingaruka za metformin ho 25%.
Berberine ishobora kuba umuti ukwiriye wo kugabanya isukari mu maraso, ariko hakenewe ubushakashatsi bwinshi.
Ikigo cy’Igihugu gishinzwe Ubuzima Bwuzuzanya n’Ubufatanye (NCCIH) kivuga ko goldenrod, irimo berberine, idashobora guteza ingaruka mbi mu gihe gito niba abantu bakuru bayinywa. Ariko, nta makuru ahagije agaragaza ko ari nziza ku ikoreshwa ry’igihe kirekire.
Mu bushakashatsi ku nyamaswa, abahanga mu bya siyansi bagaragaje ingaruka zikurikira bitewe n'ubwoko bw'inyamaswa, ingano yayo n'igihe ikoreshwa:
Ni ngombwa kubanza kuvugana na muganga wawe mbere yo gufata berberine cyangwa izindi nyongeramusaruro kuko zishobora kuba zidafite umutekano kandi zishobora kuba zitabereye buri wese. Umuntu wese ufite ubwivumbure ku bimera agomba kureka kubikoresha ako kanya.