Berberine, cyangwa hydrochloride ya berberine, ni uruganda ruboneka mu bimera byinshi. Irashobora gufasha kuvura indwara nka diyabete, cholesterol nyinshi hamwe n'umuvuduko ukabije w'amaraso. Ariko, ingaruka mbi zirashobora kubamo igifu no kugira isesemi.
Berberine imaze imyaka ibihumbi nubuvuzi gakondo bwabashinwa na Ayurvedic. Ikora mumubiri muburyo butandukanye kandi irashobora gutera impinduka mumasemburo yumubiri.
Ubushakashatsi kuri berberine bwerekana ko bushobora kuvura indwara zitandukanye ziterwa na metabolike, harimo diyabete, umubyibuho ukabije, n'indwara z'umutima. Irashobora kandi guteza imbere ubuzima bwo munda.
Nubwo berberine isa nkaho ifite umutekano kandi ifite ingaruka nke, ugomba kubaza muganga mbere yo kuyifata.
Berberine irashobora kuba imiti igabanya ubukana. Ubushakashatsi bwakozwe mu 2022 bwerekanye ko berberine ifasha guhagarika imikurire ya Staphylococcus aureus.
Ubundi bushakashatsi bwerekanye ko berberine ishobora kwangiza ADN na proteyine za bagiteri zimwe na zimwe.
Ubushakashatsi bwerekana ko berberine ifite imiti igabanya ubukana, bivuze ko ishobora gufasha kuvura diyabete nizindi ndwara zijyanye no gutwika.
Ubushakashatsi bwerekana ko berberine ishobora kuba ingirakamaro mu kuvura diyabete. Ubushakashatsi bwerekanye ko bushobora kugira ingaruka nziza kuri:
Isesengura rimwe naryo ryagaragaje ko guhuza berberine n'umuti ugabanya isukari mu maraso byagize akamaro kuruta ibiyobyabwenge byonyine.
Nk’uko ubushakashatsi bwakozwe mu mwaka wa 2014 bubitangaza, berberine yerekana amasezerano nk'umuti ushobora kuvura diyabete, cyane cyane ku bantu badashobora gufata imiti igabanya ubukana kubera indwara z'umutima, kunanirwa kw'umwijima, cyangwa ibibazo by'impyiko.
Ubundi bushakashatsi bwakozwe mubitabo bwerekanye ko berberine ihujwe nubuzima bwahinduye isukari mu maraso kuruta guhindura imibereho yonyine.
Berberine isa nkaho ikora protein kinase ikora AMP, ifasha kugenzura imikoreshereze yumubiri wisukari yamaraso. Abashakashatsi bemeza ko iki gikorwa gishobora gufasha kuvura diyabete n'ibibazo bijyanye n'ubuzima nk'umubyibuho ukabije na cholesterol nyinshi.
Ubundi meta-isesengura rya 2020 ryerekanye iterambere ryuburemere bwumubiri hamwe nibipimo bya metabolike nta kwiyongera gukomeye mubikorwa bya enzyme yumwijima.
Nyamara, abahanga bakeneye gukora ubushakashatsi bunini, buhumye-buhumyi kugirango bamenye neza umutekano nibikorwa bya berberine.
Vugana na muganga mbere yo gufata berberine ya diyabete. Ntishobora kuba ibereye abantu bose kandi irashobora gukorana nindi miti.
Urwego rwo hejuru rwa cholesterol hamwe na lipoprotein (LDL) triglyceride nkeya birashobora kongera ibyago byo kurwara umutima ndetse nubwonko.
Ibimenyetso bimwe byerekana ko berberine ishobora gufasha kugabanya LDL ya cholesterol na triglyceride. Dukurikije isuzuma rimwe, ubushakashatsi bw’inyamaswa n’abantu bwerekana ko berberine igabanya cholesterol.
Ibi birashobora gufasha kugabanya LDL, cholesterol "mbi", no kongera HDL, cholesterol "nziza".
Isubiramo ryibitabo byerekanye ko berberine ihujwe nimpinduka zubuzima bigira akamaro cyane mukuvura cholesterol nyinshi kuruta guhindura imibereho yonyine.
Abashakashatsi bemeza ko berberine ishobora gukora kimwe n’imiti igabanya cholesterol idateye ingaruka zimwe.
Isubiramo ryibitabo ryerekanye ko berberine yagize akamaro gakomeye hamwe n’imiti igabanya umuvuduko wamaraso kuruta iyonyine.
Byongeye kandi, ibisubizo bivuye mu bushakashatsi bw’imbeba byerekana ko berberine ishobora gutinda gutangira umuvuduko ukabije wamaraso kandi ikanafasha kugabanya ubukana bwayo mugihe umuvuduko ukabije wamaraso ubaye.
Isuzuma rimwe ryagaragaje ko ibiro byinshi byagabanutse ku bantu bafata miligarama 750 (mg) za barberi kabiri buri munsi mu mezi 3. Barberry ni igihingwa kirimo berberine nyinshi.
Byongeye kandi, ubushakashatsi bwimpumyi ebyiri bwerekanye ko abantu barwaye syndrome de metabolike bafashe mg 200 za barberi inshuro eshatu kumunsi bafite igipimo cyo hasi cyumubiri.
Itsinda rikora ubundi bushakashatsi ryerekanye ko berberine ishobora gukora tissue adipose. Iyi nyama ifasha umubiri guhindura ibiryo mubushyuhe bwumubiri, kandi kongera imbaraga birashobora gufasha kuvura umubyibuho ukabije hamwe na syndrome de metabolike.
Ubushakashatsi bumwe bwerekana ko berberine ikora kimwe na metformin yibiyobyabwenge, abaganga bakunze gutegeka kuvura diyabete yo mu bwoko bwa 2. Mubyukuri, berberine irashobora kuba ifite ubushobozi bwo guhindura bagiteri zo munda, zishobora gufasha kuvura umubyibuho ukabije na diyabete.
Indwara ya polycystic ovary syndrome (PCOS) ibaho mugihe abagore bafite imisemburo myinshi ya hormone zabagabo. Indwara ya syndrome ni ubusembwa bwa hormone na metabolike bushobora gutera ubugumba nibindi bibazo byubuzima.
Indwara ya polycystic ovary ifitanye isano nibibazo byinshi berberine ishobora gufasha gukemura. Kurugero, abantu bafite PCOS nabo bashobora kugira:
Abaganga rimwe na rimwe bategeka metformin, imiti ya diyabete, kuvura PCOS. Kubera ko berberine ifite ingaruka zisa na metformin, birashobora kandi kuba uburyo bwiza bwo kuvura PCOS.
Isuzuma rifatika ryasanze berberine itanga icyizere mu kuvura syndrome ya polycystic ovary hamwe na insuline irwanya insuline. Ariko, abanditsi bavuga ko kwemeza izo ngaruka bisaba ubundi bushakashatsi.
Berberine irashobora gutera impinduka muri molekile ya selile, ishobora kugira izindi nyungu: kurwanya kanseri.
Ubundi bushakashatsi bwerekana ko berberine ifasha kuvura kanseri ibuza iterambere ryayo ndetse nubuzima busanzwe. Irashobora kandi kugira uruhare mukwica selile.
Hashingiwe kuri aya makuru, abanditsi bavuga ko berberine ari “imiti ikora neza, itekanye, kandi ihendutse” imiti igabanya ubukana.
Ariko, ni ngombwa kwibuka ko abashakashatsi bize gusa ingaruka za berberine kuri selile kanseri muri laboratoire ntabwo ari mubantu.
Nk’uko ubushakashatsi bumwe bwashyizwe ahagaragara mu 2020, niba berberine ishobora gufasha kuvura kanseri, gutwika, diyabete n'izindi ndwara, bishobora guterwa n'ingaruka zabyo kuri mikorobe yo mu nda. Abahanga bavumbuye isano iri hagati ya microbiome yo munda (koloni ya bagiteri mu mara) nibi bihe.
Berberine ifite antibacterial kandi ikuraho bagiteri zangiza mu mara, bityo bigatuma imikurire ya bagiteri nziza.
Mu gihe ubushakashatsi bwakozwe ku bantu n’imbeba bwerekana ko ibyo bishobora kuba ukuri, abahanga bavuga ko hakenewe ubushakashatsi bwinshi kugira ngo hemezwe uburyo berberine igira ingaruka ku bantu kandi niba ari byiza kuyikoresha.
Ishyirahamwe ry’Abanyamerika ry’abaganga ba Naturopathique (AANP) rivuga ko inyongera za berberine ziboneka mu buryo bwuzuye cyangwa bwa capsule.
Bongeraho ko ubushakashatsi bwinshi busaba gufata 900-1500 mg kumunsi, ariko abantu benshi bafata mg 500 inshuro eshatu kumunsi. Icyakora, AANP irahamagarira abantu kugisha inama muganga mbere yo gufata berberine kugirango barebe niba ari byiza kuyikoresha ndetse no ku kigero gishobora gufatwa.
AANP ivuga ko niba umuganga yemeye ko berberine ifite umutekano kuyikoresha, abantu bagomba no gusuzuma ikirango cy’ibicuruzwa kugira ngo babone icyemezo cy’abandi bantu, nka National Science Foundation (NSF) cyangwa NSF International, nk'uko AANP ibivuga.
Abanditsi b'ubushakashatsi bwakozwe mu mwaka wa 2018 basanze ibikubiye muri capsules zitandukanye za berberine zitandukanye cyane, bikaba byaviramo urujijo ku bijyanye n'umutekano na dosiye. Ntabwo basanze ibiciro biri hejuru byanze bikunze byerekana ubuziranenge bwibicuruzwa.
Ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA) ntabwo kigenga inyongeramusaruro. Nta cyemeza ko inyongera zifite umutekano cyangwa zifite akamaro, kandi ntabwo buri gihe bishoboka kugenzura ubwiza bwibicuruzwa.
Abahanga bavuga ko berberine na metformin bisangiye ibintu byinshi kandi byombi bishobora kuba ingirakamaro mu kuvura diyabete yo mu bwoko bwa 2.
Ariko, mugihe umuganga yandikiye metformin kumuntu, ntibakagombye gufata berberine nkubundi buryo batabanje kubiganiraho na muganga wabo.
Abaganga bazagena igipimo gikwiye cya metformin kumuntu ukurikije ubushakashatsi bwubuvuzi. Ntibishoboka kumenya uburyo inyongera zihuye naya mafranga.
Berberine irashobora gukorana na metformine kandi ikagira ingaruka ku isukari yo mu maraso, bikagorana kuyigenzura. Mu bushakashatsi bumwe, gufata berberine na metformin hamwe byagabanije ingaruka za metformine 25%.
Berberine hari igihe ishobora kuba metformine yo kugenzura isukari mu maraso, ariko birakenewe ubushakashatsi bwinshi.
Ikigo cy’igihugu gishinzwe ubuzima bwuzuye kandi bwuzuye (NCCIH) kivuga ko goldrod, irimo berberine, bidashoboka ko byatera ingaruka zikomeye mu gihe gito niba abantu bakuru babifata mu kanwa. Ariko, nta makuru ahagije yerekana ko ari umutekano mugukoresha igihe kirekire.
Mu bushakashatsi bw’inyamaswa, abahanga bagaragaje ingaruka zikurikira bitewe n'ubwoko bw'inyamaswa, ingano n'igihe cyo kuyobora:
Ni ngombwa kuvugana na muganga wawe mbere yo gufata berberine cyangwa ibindi byongeweho kuko bishobora kuba bidafite umutekano kandi ntibishobora kuba byiza kuri bose. Umuntu wese ufite allergie reaction kubicuruzwa byose byibyatsi agomba guhagarika kubikoresha ako kanya.